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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
A novel deletion in progranulin gene is associated with FTDP-17 and CBS.
Neurobiol. Aging 29, 427-435 (2008)
In the last decade familial frontotemporal dementia (FFTD) has emerged as a distinct clinical disease entity characterized by clinical and genetic heterogeneity. Here, we provide an extensive clinical and genetic characterization of two Italian pedigrees presenting with FFTD (FAM047: 5 patients, 5 unaffected; FAM071: 4 patients, 11 unaffected). Genetic analysis showed a conclusive linkage (LOD score for D17S791/D17S951: 4.173) to chromosome 17 and defined a candidate region containing MAPT and PGRN genes. Recombination analysis assigned two different disease haplotypes to FAM047 and FAM071. In affected subjects belonging to both families, we identified a novel 4 bp deletion mutation in exon 7 of PGRN gene (Leu271LeufsX10) associated with a variable clinical presentation ranging from FTDP-17 to corticobasal syndrome. The age-related penetrance was gender dependent. Both mutations in MAPT and PGRN genes are associated with highly variable clinical phenotypes. Despite the profound differences in the biological functions of the encoded proteins, it is not possible to define a clinical phenotype distinguishing the disease caused by mutations in MAPT and PGRN genes.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
5.607
1.450
62
93
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Frontotemporal dementia; Corticobasal syndrome; Linkage analysis; PGRN; Mutation; Genotype–phenotype correlation
Sprache
englisch
Veröffentlichungsjahr
2008
HGF-Berichtsjahr
0
ISSN (print) / ISBN
0197-4580
e-ISSN
1558-1497
Zeitschrift
Neurobiology of Aging
Quellenangaben
Band: 29,
Heft: 3,
Seiten: 427-435
Verlag
Elsevier
Verlagsort
New York, NY [u.a.]
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Human Genetics (IHG)
POF Topic(s)
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Forschungsfeld(er)
Genetics and Epidemiology
PSP-Element(e)
G-500700-001
Erfassungsdatum
2008-10-21