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Mueller, J.C.* ; Riemenschneider, M.* ; Schoepfer-Wendels, A.* ; Gohlke, H. ; Konta, L.* ; Friedrich, P.* ; Illig, T. ; Laws, S.* ; Förstl, H.* ; Kurz, A.

Weak independent association signals between IDE polymorphisms, Alzheimer's disease and cognitive measures.

Neurobiol. Aging 28, 727-734 (2007)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Functional and genetic studies suggest that insulin-degrading enzyme (IDE) may be a strong functional and positional candidate. As there is a lack of consensus in regards to the level and location of IDE association signals we aimed to clarify these discrepancies through genotyping 28 SNPs in a large case-control collective together with quantitative measures of cognitive ability (MMSE). Four SNPs (rs11187007, rs2149632_ide12, rs11187033, rs11187040) were found to be associated with AD (nominal p<0.01). Tests with MMSE scores adjusted for disease duration identified associations, with the most significant result for rs1999763 (nominal p=0.008). Similarly, different reconstructed IDE haplotypes were associated with AD and higher MMSE scores. The association signals are only borderline significant after adjustment for multiple testing, but add further evidence to previous published results on the association between IDE and AD or MMSE. A subgroup analysis indicated more prominent associations with AD in younger, and with MMSE in older patients. There may be two independent effects mediated by IDE variants, risk for AD and modification of disease progression.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter IDE; Genetic association study; Haplotype; Alzheimer's disease; SNP; LD; Mini mental state examination
Sprache englisch
Veröffentlichungsjahr 2007
HGF-Berichtsjahr 2007
ISSN (print) / ISBN 0197-4580
e-ISSN 1558-1497
Zeitschrift Neurobiology of Aging
Quellenangaben Band: 28, Heft: 5, Seiten: 727-734 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort New York, NY [u.a.]
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
POF Topic(s) 30503 - Chronic Diseases of the Lung and Allergies
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-503900-003
PubMed ID 16675064
DOI 10.1016/j.neurobiolaging.2006.03.009
WOS ID 000245109700011
Scopus ID 33847379373
Erfassungsdatum 2007-05-15
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