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Weissinger, E.M. ; Henderson, D.W.* ; Mischak, H. ; Goodnight, J.* ; Frederic Mushinski, J.*

Induction of plasmacytomas that secrete monoclonal anti-peptide antibodies by retroviral transformation.

J. Immunol. Methods 168, 123-130 (1994)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
ABL-MYC, a retrovirus that coexpresses v-abl and c-myc, was used to infect six BALB/c mice that had been immunized twice with a KLH-conjugated peptide that consisted of the 18 carboxyterminal amino acids of protein kinase C-η (PKC-η). All mice developed transplantable, monoclonal plasmacytomas, and five out of six plasmacytomas secreted antigen-specific antibodies, even after transplantation. All these antibodies recognized PKC-η on Western blots of crude cell lysates and did not cross react with other isoforms of the PKC family.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Abl-myc ; Monoclonal Antibody ; Proteinkinase C-η ; Retrovirus
ISSN (print) / ISBN 0022-1759
e-ISSN 1872-7905
Zeitschrift Journal of Immunological Methods
Quellenangaben Band: 168, Heft: 1, Seiten: 123-130 Artikelnummer: , Supplement: ,
Verlag Elsevier
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Clinical Molecular Biology and Tumor Genetics (K.MOLBI)