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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Initiation of enzyme-altered foci by the synthetic steroid cyproterone acetate in rat liver foci bioassay.
Carcinogenesis 14, 1229-1231 (1993)
Cyproterone acetate (CPA) is a synthetic steroid which is used in oral contraceptive and anti-androgen formulations. It has previously been classified as a tumor promoter in rat liver. Recent studies have shown that CPA induces DNA repair synthesis in isolated hepatocytes, and this implies that CPA is genotoxic. We studied the initiating activity of CPA in vivo by means of a rat liver foci bioassay, using weanling female Sprague-Dawley rats. The results show that CPA induces adenosine-triphosphatase-deficient and γ-glutamyltranspeptidase-positive putative preneoplastic foci in a dose-dependent manner. This indicates that CPA has not only promoting but also initiating activity and may therefore act as a complete carcinogen in rat liver.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
ISSN (print) / ISBN
0143-3334
e-ISSN
1460-2180
Zeitschrift
Carcinogenesis
Quellenangaben
Band: 14,
Heft: 6,
Seiten: 1229-1231
Verlag
Oxford University Press
Begutachtungsstatus
Peer reviewed
Institut(e)
Institut für Toxikologie