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    Influence of different inhibitors on the activity of the RAD54 dependent step of DNA repair in Saccharomyces cerevisiae.
        
        Radiat. Environ. Biophys. 24, 1-7 (1985)
    
    
    
				The recombinagenic pathway of DNA repair in yeast was characterized by the effect of different inhibitors on the temperature-dependent survival after γ-irradiation in haploid cells of the thermoconditional mutant rad54-3. Blocking protein synthesis with cycloheximide in replicating cells caused partial inhibition of the RAD54 dependent function but some repair activity remained detectable. This indicates that γ-rays can induce RAD54 activity above some constitutive level of function. Inhibition of DNA replication by hydroxyurea efficiently blocked the RAD54 dependent function in stationary-phase cells but not in logarithmic-phase cells. In logarithmic-phase cells, we found a strong inhibitory effect of caffeine on the RAD54 mediated repair process.
			
			
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        Publikationstyp
        Artikel: Journalartikel
    
 
    
        Dokumenttyp
        Wissenschaftlicher Artikel
    
 
     
    
     
     
    
    
        Sprache
        englisch
    
 
    
        Veröffentlichungsjahr
        1985
    
 
     
    
        HGF-Berichtsjahr
        0
    
 
    
    
        ISSN (print) / ISBN
        0301-634X
    
 
    
        e-ISSN
        1432-2099
    
 
     
     
     
	     
	 
	 
    
        Zeitschrift
        Radiation and Environmental Biophysics
    
 
		
    
        Quellenangaben
        
	    Band: 24,  
	    Heft: 1,  
	    Seiten: 1-7 
	    
	    
	
    
 
  
         
        
            Verlag
            Springer
        
 
         
	
         
         
         
         
         
	
         
         
         
    
         
         
         
         
         
         
         
    
        Begutachtungsstatus
        Peer reviewed
    
 
    
        Institut(e)
        Abteilung für Strahlenbiologie und Biophysik
    
 
     
     
     
     
     	
    
        Scopus ID
        0021968849
    
    
    
        Erfassungsdatum
        1985-12-31