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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Human liver debrisoquine 4-hydroxylase: Test for specifity toward various monooxygenase substrates and model of the active site.
Arch. Toxicol. 60, 89-90 (1987)
Polyclonal antibodies raised toward a debrisoquine 4-hydroxylating cytochrome P-450 species purified from rat liver (P-450UTA) were used to determine which monooxygenase reactions are linked to debrisoquine hydroxylation in human liver. Anti P-450UTA did not inhibit the oxidation of dimethylnitrosamine, morphine, diazepam, vinylidene chloride, trichloroethylene, benzo(a)pyrene and its 7.8-dihydrodiol, but was inhibitory for the hydroxylation of debrisoquine, (±)-bufuralol, lasiocarpine and monocrotaline. A model interpreting the substrate specificity of the human liver enzyme is presented. .
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Cytochrome P-450 ; Debrisoquine ; Human Liver
ISSN (print) / ISBN
0340-5761
e-ISSN
1432-0738
Zeitschrift
Archives of Toxicology
Quellenangaben
Band: 60,
Heft: 1-3,
Seiten: 89-90
Verlag
Springer
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institut für Toxikologie und Biochemie