PuSH - Publikationsserver des Helmholtz Zentrums München: The murine pan T cell marker CD96 is an adhesion receptor for CD155 and nectin-1.

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Seth, S.* ; Maier, M.K.* ; Qiu, Q.* ; Ravens, I.* ; Kremmer, E. ; Forster, R.* ; Bernhardt, G.*

The murine pan T cell marker CD96 is an adhesion receptor for CD155 and nectin-1.

Biochem. Biophys. Res. Commun. 364, 959-965 (2007)

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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.

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The CD155 ligand CD96 is an immunoglobulin-like protein tentatively allocated to the repertoire of human NK receptors. We report here that the CD96/CD155-interaction is preserved between man and mouse although both receptors are only moderately conserved in amino acid sequence. Moreover, murine CD96 (mCD96) binds to nectin-1, a receptor related to CD155. Applying newly generated monoclonal antibodies specifically recognizing mCD96, an expression profile is revealed resembling closely that of human CD96 (hCD96) on cells of hematopoietic origin. A panel of anti-mCD96 but also recently established anti-mCD155 antibodies effectively prevents formation of CD96/CD155-complexes. This was exploited to demonstrate that the only available receptor for mCD96 present on thymocytes is mCD155. Moreover, T cell adhesion to insect cells expressing mCD155 is blocked by these antibodies depending on the T cell subtype. These results suggest a function of the CD96/CD155-adhesion system in T cell biology.

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