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Giusti, S.A.* ; Vogl, A.M.* ; Brockmann, M.M.* ; Vercelli, C.A.* ; Rein, M.L.* ; Trümbach, D. ; Wurst, W. ; Cazalla, D.* ; Stein, V.* ; Deussing, J.M.* ; Refojo, D.*

MicroRNA-9 controls dendritic development by targeting REST.

eLife 3:e02755 (2014)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
MicroRNAs (miRNAs) are conserved noncoding RNAs that function as posttranscriptional regulators of gene expression. miR-9 is one of the most abundant miRNAs in the brain. Although the function of miR-9 has been well characterized in neural progenitors, its role in dendritic and synaptic development remains largely unknown. In order to target miR-9 in vivo, we developed a transgenic miRNA sponge mouse line allowing conditional inactivation of the miR-9 family in a spatio-temporal-controlled manner. Using this novel approach, we found that miR-9 controls dendritic growth and synaptic transmission in vivo. Furthermore, we demonstrate that miR-9-mediated downregulation of the transcriptional repressor REST is essential for proper dendritic growth.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Rest ; Dendrite Development ; Mir-9 ; Mir-9 Reporter ; Mir-9 Sponge ; Mouse ; Neuroscience
ISSN (print) / ISBN 2050-084X
e-ISSN 2050-084X
Zeitschrift eLife
Quellenangaben Band: 3, Heft: , Seiten: , Artikelnummer: e02755 Supplement: ,
Verlag eLife Sciences Publications
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Developmental Genetics (IDG)
CCG Molecular Neurogenetics (IDG-KMN)