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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Extracellular cell stress proteins as biomarkers of human disease.
Biochem. Soc. Trans. 42, 1744-1751 (2014)
Although heat-shock (cell stress) proteins are commonly considered as being intracellular molecular chaperones that undertake a number of cytoprotective and cellular housekeeping functions, there is now a wealth of evidence to indicate that these proteins can be released by cells via active processes. Many molecular chaperones are secreted, or exist as cell surface proteins which can act as powerful signalling agonists and also as receptors for selected ligands. Levels of heat-shock (cell stress) proteins in biological fluids are now being associated with a plethora of clinical conditions, and these proteins therefore have potential utility as biomarkers of disease and/or response to therapeutic intervention. The present article summarizes current knowledge relating to extracellular cell stress proteins as biomarkers of human disease.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Biomarker ; Cancer ; Cell Stress Protein ; Enzyme Immunoassay ; Heat-shock Protein ; Molecular Chaperone
ISSN (print) / ISBN
0300-5127
e-ISSN
1470-8752
Zeitschrift
Biochemical Society Transactions
Quellenangaben
Band: 42,
Heft: 6,
Seiten: 1744-1751
Verlag
Portland Press
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
CCG Innate Immunity in Tumor Biology (IBMI-KTB)