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Pockley, A.G.* ; Henderson, B.* ; Multhoff, G.

Extracellular cell stress proteins as biomarkers of human disease.

Biochem. Soc. Trans. 42, 1744-1751 (2014)
Verlagsversion DOI PMC
Open Access Gold
Although heat-shock (cell stress) proteins are commonly considered as being intracellular molecular chaperones that undertake a number of cytoprotective and cellular housekeeping functions, there is now a wealth of evidence to indicate that these proteins can be released by cells via active processes. Many molecular chaperones are secreted, or exist as cell surface proteins which can act as powerful signalling agonists and also as receptors for selected ligands. Levels of heat-shock (cell stress) proteins in biological fluids are now being associated with a plethora of clinical conditions, and these proteins therefore have potential utility as biomarkers of disease and/or response to therapeutic intervention. The present article summarizes current knowledge relating to extracellular cell stress proteins as biomarkers of human disease.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Biomarker ; Cancer ; Cell Stress Protein ; Enzyme Immunoassay ; Heat-shock Protein ; Molecular Chaperone
Sprache englisch
Veröffentlichungsjahr 2014
HGF-Berichtsjahr 2014
ISSN (print) / ISBN 0300-5127
e-ISSN 1470-8752
Zeitschrift Biochemical Society Transactions
Quellenangaben Band: 42, Heft: 6, Seiten: 1744-1751 Artikelnummer: , Supplement: ,
Verlag Portland Press
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biological and Medical Imaging (IBMI)
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-521400-001
PubMed ID 25399600
DOI 10.1042/BST20140205
WOS ID WOS:000345427100044
Scopus ID 84911874159
Erfassungsdatum 2014-11-27
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