PuSH - Publikationsserver des Helmholtz Zentrums München: Genome-wide meta-analyses of plasma renin activity and concentration reveal association with the kininogen 1 and prekallikrein genes.

Informationen

Hinweise zu Qualitätskriterien von Zeitschriften

Open-Access-Richtlinie der Helmholtz-Gemeinschaft 2016

CC Licencences

Metriken für Publikationen

Navigation

Startseite

English

EVA: Veröffentlichen

Neuer EVA Antrag

Recherche

Erweiterte Suche

Durchblättern nach ...

... HMGU-Autoren/Konsortien

... Organisationsstruktur

... Zeitschriften

... Publikationstypen

... Forschungsdaten

... Arbeitsgruppen

... Erscheinungsjahr

Publikationen im Überblick

Statistik

HGF Fortschrittsbericht

OA Publikationen

Eintragen

Neue Publikation eintragen

Neue Publikation holen aus...

...EVA

Fehlende Publikation melden

Highlights

Suche

Hilfe & Kontakt

Ansprechpartner

Hilfe

Datenschutz

Helmholtz Open Science

Bibliometrische Indikatoren

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Lieb, W.* ; Chen, M.H.* ; Teumer, A.* ; de Boer, R.A.* ; Lin, H.* ; Fox, E.R.* ; Musani, S.K.* ; Wilson, J.G.* ; Wang, T.J.* ; Völzke, H.* ; Petersen, A.K. ; Meisinger, C. ; Nauck, M.* ; Schlesinger, S.* ; Li, Y.* ; Ménard, J.* ; Hercberg, S.* ; Wichmann, H.-E. ; Völker, U.* ; Rawal, R. ; Bidlingmaier, M.* ; Hannemann, A.* ; Dörr, M.* ; Rettig, R.* ; van Gilst, W.H.* ; van Veldhuisen, D.J.* ; Bakker, S.J.* ; Navis, G.* ; Wallaschofski, H.* ; Meneton, P.* ; van der Harst, P.* ; Reincke, M.* ; Vasan, R.S.* ; CKDGen Consortium (*) ; ICBP Consortium (*) ; EchoGen Consortium (*)

Genome-wide meta-analyses of plasma renin activity and concentration reveal association with the kininogen 1 and prekallikrein genes.

Circ. Cardiovasc. Genet. 8, 131-140 (2015)

Verlagsversion

DOI

PMC

	Free by publisher

Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.

Abstract
Metriken
Zusatzinfos

BACKGROUND: -The renin-angiotensin-aldosterone-system (RAAS) is critical for regulation of blood pressure and fluid balance and influences cardiovascular remodeling. Dysregulation of the RAAS contributes to cardiovascular and renal morbidity. The genetic architecture of circulating RAAS components is incompletely understood. METHODS AND RESULTS: -We meta-analyzed genome-wide association data for plasma renin activity (n=5,275), plasma renin concentrations (n=8,014) and circulating aldosterone (n=13,289) from up to four population-based cohorts of European and European-American ancestry, and assessed replication of the top results in an independent sample (n=6,487). Single nucleotide polymorphisms (SNPs) in two independent loci displayed associations with plasma renin activity at genome-wide significance (p<5x10(-8)). A third locus was close to this threshold (rs4253311 in kallikrein B [KLKB1], p=5.5x10(-8)). Two of these loci replicated in an independent sample for both plasma renin and aldosterone concentrations (SNP rs5030062 in kininogen 1 [KNG1]: p=0.001 for plasma renin, p=0.024 for plasma aldosterone concentration; rs4253311 with p<0.001 for both plasma renin and aldosterone concentration). SNPs in the NEBL gene reached genome-wide significance for plasma renin concentration in the discovery sample (top SNP rs3915911, p=8.81x10(-9)), but did not replicate (p=0.81). No locus reached genome-wide significance for aldosterone. SNPs rs5030062 and rs4253311 were not related to blood pressure or renal traits; in a companion study, variants in the kallikrein B locus were associated with B-type natriuretic peptide concentrations in African-Americans. CONCLUSIONS: -We identified two genetic loci (kininogen 1 and kallikrein B) influencing key components of the RAAS, consistent with the close interrelation between the kallikrein-kinin system and the RAAS.

Impact Factor

Scopus SNIP

Web of Science
Times Cited

Scopus
Cited By

Altmetric

4.600

1.350