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    Differentiation, expansion, and homeostasis of autoreactive T cells in type 1 diabetes mellitus.
        
        Curr. Diab. Rep. 9, 113-118 (2009)
    
    
    
				Autoreactive T cells play a major role in the pathogenesis of type 1 diabetes mellitus (T1DM) and are considered a major target of immunomodulatory strategies aimed at preventing or delaying the disease onset. However, the T-cell response against insulin-producing beta cells is still poorly understood. T cells potentially able to recognize and destroy beta cells are present in most individuals, but only in a few do they differentiate into pathogenic effectors. Recent and novel findings in T-cell biology on the dynamics of T-cell activation and memory maintenance are shedding new light on the general mechanisms of the T-cell response. In this article, we discuss how new discoveries about T-cell differentiation, expansion, and homeostasis could help to clarify mechanisms of autoimmunity that lead to T1DM.
			
			
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        Publikationstyp
        Artikel: Journalartikel
    
 
    
        Dokumenttyp
        Wissenschaftlicher Artikel
    
 
     
    
     
     
    
    
        Sprache
        englisch
    
 
    
        Veröffentlichungsjahr
        2009
    
 
     
    
        HGF-Berichtsjahr
        0
    
 
    
    
        ISSN (print) / ISBN
        1534-4827
    
 
    
        e-ISSN
        1539-0829
    
 
     
     
     
	     
	 
	 
    
        Zeitschrift
        Current Diabetes Reports
    
 
		
    
        Quellenangaben
        
	    Band: 9,  
	    Heft: 2,  
	    Seiten: 113-118 
	    
	    
	
    
 
  
         
        
            Verlag
            Springer
        
 
        
            Verlagsort
            Heidelberg [u.a.]
        
 
	
         
         
         
         
         
	
         
         
         
    
         
         
         
         
         
         
         
    
        Begutachtungsstatus
        Peer reviewed
    
 
    
        Institut(e)
        Institute of Pancreatic Islet Research (IPI)
    
 
     
     
     
     
     	
    
        PubMed ID
        19323955
    
    
        Erfassungsdatum
        2009-12-31