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Membrane rafting: from apical sorting to phase segregation.
FEBS Lett. 584, 1685-1693 (2010)
In this review we describe the history of the development of the raft concept for membrane sub-compartmentalization. From its early beginnings as a mechanism for apical sorting in epithelial cells the concept has evolved to a general principle for membrane organisation. After a shaky start with crude methodology based on detergent extraction the field has become increasingly sophisticated, employing a host of different methods that support the existence of dynamic raft domains in membranes. These are composed of fluctuating nanoscale assemblies of sphingolipid, cholesterol and proteins that can be stabilized to coalesce, forming platforms that function in membrane signalling and trafficking.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Sprache
englisch
Veröffentlichungsjahr
2010
HGF-Berichtsjahr
0
ISSN (print) / ISBN
0014-5793
e-ISSN
1873-3468
Zeitschrift
FEBS Letters
Quellenangaben
Band: 584,
Heft: 9,
Seiten: 1685-1693
Verlag
Elsevier
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Pancreatic Islet Research (IPI)
PubMed ID
20036659
Erfassungsdatum
2010-12-31