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Langer, H.F.* ; Orlova, V.V.* ; Xie, C.* ; Kaul, S.* ; Schneider, D.* ; Lonsdorf, A.S.* ; Fahrleitner, M.* ; Choi, E.Y.* ; Dutoit, V.* ; Pellegrini, M.* ; Grossklaus, S.* ; Nawroth, P.P.* ; Baretton, G.* ; Santoso, S.* ; Hwang, S.T.* ; Arnold, B.* ; Chavakis, T.*

A novel function of junctional adhesion molecule-C in mediating melanoma cell metastasis.

Cancer Res. 71, 4096-4105 (2011)

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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.

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Hematogenous dissemination of melanoma is a life-threatening complication of this malignant tumor. Here, we identified junctional adhesion molecule-C (JAM-C) as a novel player in melanoma metastasis to the lung. JAM-C expression was identified in human and murine melanoma cell lines, in human malignant melanoma, as well as in metastatic melanoma including melanoma lung metastasis. JAM-C expressed on both murine B16 melanoma cells as well as on endothelial cells promoted the transendothelial migration of the melanoma cells. We generated mice with inactivation of JAM-C. JAM-C(-/-) mice as well as endothelial-specific JAM-C-deficient mice displayed significantly decreased B16 melanoma cell metastasis to the lung, whereas treatment of mice with soluble JAM-C prevented melanoma lung metastasis. Together, JAM-C represents a novel therapeutic target for melanoma metastasis.

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