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Lachenmayer, A.* ; Lichtenauer, U.D.* ; Cox, T.* ; Schott, M.* ; Malendowicz, L.K.* ; Goretzki, P.E.* ; Cupisti, K.* ; Scherbaum, W.A.* ; Bornstein, S.R.* ; Willenberg, H.S.*

Nestin as a marker in the classification of adrenocortical tumors.

Horm. Metab. Res. 41, 397-401 (2009)

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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.

Abstract
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Expression of the intermediate filament, nestin, was long believed to be restricted to neuroectodermal stem cells. However, nestin expression has recently been detected in several tumors. Since adrenocortical carcinoma, a tumor entity still very difficult to classify, may gain the ability to aberrantly express neuroectodermal proteins including chromogranin A and synaptophysin, we asked the question whether nestin might also be detected in adrenocortical carcinomas, and if so, whether it might serve as a tool for clinical pathology. Therefore, we studied the expression of nestin in normal adrenal glands, adrenocortical adenomas, and adrenocortical cancers using specific immunohistochemistry and semi-quantitative reverse transcriptase-polymerase chain reaction. Immunostaining was nestin-positive in 1 out of 9 normal adrenal glands (11%), 2 out of 20 adrenocortical adenomas (10%), and 13 out of 16 adrenocortical carcinomas (81%). Expression of nestin mRNA could be detected in all microdissected tissues, independently of their grade of dedifferentiation. We conclude that our findings provide further evidence that nestin, as a marker, is not restricted to neuronal stem cells and nestin expression is worth to be studied in adrenocortical tumors.

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