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Kapasa, M.* ; Serafimidis, I.* ; Gavalas, A.* ; Kossida, S.*

Identification of phylogenetically conserved enhancer elements implicated in pancreas development in the WISP1 and CTGF orthologs.

Genomics 92, 301-308 (2008)
DOI PMC
Open Access Gold möglich sobald Verlagsversion bei der ZB eingereicht worden ist.
WISP1 and CTGF are members of the CCN family of growth factors encoding extracellular matrix proteins participating in several developmental and tumorigenic processes. Both are induced by the WNT signaling pathway, and microarray data suggest that expression of WISP1 and CTGF is repressed by Neurogenin3 (Ngn3 (NEUROG3)), a transcription factor directing specification of the endocrine pancreas. Single-cell reverse transcription polymerase chain reaction analysis suggested that this was a cell autonomous effect. To identify possible common regulatory networks involved in WISP1 and CTGF gene expression, their genomic regions were searched for common transcription factor motifs using a combination of in silico approaches and documented knowledge concerning pancreas development. This analysis revealed the presence of a conserved enhancer in both CTGF and WISP1 regulatory regions in 10 species covering a wide evolutionary distance. This enhancer contains binding sites for Ngn1/3 (NEUROG1/3) and transcription factors that are critically involved in pancreas development. Furthermore, it contained binding sites for three additional transcription factor families, which may indicate novel players are involved in this process.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Sprache englisch
Veröffentlichungsjahr 2008
HGF-Berichtsjahr 0
ISSN (print) / ISBN 0888-7543
e-ISSN 1089-8646
Zeitschrift Genomics
Quellenangaben Band: 92, Heft: 5, Seiten: 301-308 Artikelnummer: , Supplement: ,
Verlag Elsevier
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Pancreatic Islet Research (IPI)
POF Topic(s) 90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502600-003
PubMed ID 18616996
DOI 10.1016/j.ygeno.2008.06.003
Erfassungsdatum 2008-12-31
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