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Czogalla, A.*

Oral cyclosporine A - the current picture of its liposomal and other delivery systems.

Cell. Mol. Biol. Lett. 14, 139-152 (2009)
DOI PMC
Open Access Gold möglich sobald Verlagsversion bei der ZB eingereicht worden ist.
The discovery of cyclosporine A was a milestone in organ transplantation and the treatment of autoimmune diseases. However, developing an efficient oral delivery system for this drug is complicated by its poor biopharmaceutical characteristics (low solubility and permeability) and the need to carefully monitor its levels in the blood. Current research is exploring various approaches, including those based on emulsions, microspheres, nanoparticles, and liposomes. Although progress has been made, none of the formulations is flawless. This review is a brief description of the main pharmaceutical systems and devices that have been described for the oral delivery of cyclosporine A in the context of the physicochemical properties of the drug and the character of its interactions with lipid membranes.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Sprache englisch
Veröffentlichungsjahr 2009
HGF-Berichtsjahr 0
ISSN (print) / ISBN 1425-8153
e-ISSN 1689-1392
Zeitschrift Cellular & Molecular Biology Letters
Quellenangaben Band: 14, Heft: 1, Seiten: 139-152 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort Warsaw : Versita ; Berlin ; Heidelberg
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Pancreatic Islet Research (IPI)
PubMed ID 19005620
DOI 10.2478/s11658-008-0041-6
Erfassungsdatum 2009-12-31
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