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Barbosa, J.S. ; Sanchez-Gonzalez, R. ; di Giaimo, R. ; Baumgart, E.V. ; Theis, F.J. ; Götz, M. ; Ninkovic, J.

Live imaging of adult neural stem cell behavior in the intact and injured zebrafish brain.

Science 348, 789-793 (2015)
Verlagsversion DOI PMC
Free by Publisher
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Adult neural stem cells are the source for restoring injured brain tissue. We used repetitive imaging to follow single stem cells in the intact and injured adult zebrafish telencephalon in vivo and found that neurons are generated by both direct conversions of stem cells into postmitotic neurons and via intermediate progenitors amplifying the neuronal output. We observed an imbalance of direct conversion consuming the stem cells and asymmetric and symmetric self-renewing divisions, leading to depletion of stem cells over time. After brain injury, neuronal progenitors are recruited to the injury site. These progenitors are generated by symmetric divisions that deplete the pool of stem cells, a mode of neurogenesis absent in the intact telencephalon. Our analysis revealed changes in the behavior of stem cells underlying generation of additional neurons during regeneration.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Telencephalon; Regeneration; Neurogenesis; Differentiation; Quiescence; Forebrain; Model; Zone
Sprache englisch
Veröffentlichungsjahr 2015
HGF-Berichtsjahr 2015
ISSN (print) / ISBN 0036-8075
e-ISSN 1095-9203
Zeitschrift Science
Quellenangaben Band: 348, Heft: 6236, Seiten: 789-793 Artikelnummer: , Supplement: ,
Verlag American Association for the Advancement of Science (AAAS)
Verlagsort Washington
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Stem Cell Research (ISF)
Institute of Diabetes and Obesity (IDO)
Institute of Computational Biology (ICB)
POF Topic(s) 30204 - Cell Programming and Repair
30502 - Diabetes: Pathophysiology, Prevention and Therapy
30205 - Bioengineering and Digital Health
Forschungsfeld(er) Stem Cell and Neuroscience
Helmholtz Diabetes Center
Enabling and Novel Technologies
PSP-Element(e) G-500800-001
G-502294-002
G-503800-001
DOI 10.1126/science.aaa2729
WOS ID WOS:000354428700041
Scopus ID 84929340884
PubMed ID 25977550
Erfassungsdatum 2015-05-17
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