PuSH - Publikationsserver des Helmholtz Zentrums München: A metabolome-wide association study of kidney function and disease in the general population.

Navigation

Startseite

English

Recherche

Erweiterte Suche

Durchblättern nach ...

... Zeitschriften

... Publikationstypen

... Forschungsdaten

... Erscheinungsjahr

Publikationen im Überblick

Hilfe & Kontakt

Ansprechpartner

Hilfe

Datenschutz

Sekula, P.* ; Goek, O.N.* ; Quaye, L.* ; Barrios, C.* ; Levey, A.S.* ; Römisch-Margl, W. ; Menni, C.* ; Yet, I.* ; Gieger, C. ; Inker, L.A.* ; Adamski, J. ; Gronwald, W.* ; Illig, T. ; Dettmer, K.* ; Krumsiek, J. ; Oefner, P.J.* ; Valdes, A.M.* ; Meisinger, C. ; Coresh, J.* ; Spector, T.D.* ; Mohney, R.P.* ; Suhre, K. ; Kastenmüller, G. ; Köttgen, A.*

A metabolome-wide association study of kidney function and disease in the general population.

J. Am. Soc. Nephrol. 27, 1175-1188 (2016)

Verlagsversion

DOI

PMC

	Free by publisher

Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.

Abstract
Metriken
Zusatzinfos

Small molecules are extensively metabolized and cleared by the kidney. Changes in serum metabolite concentrations may result from impaired kidney function and can be used to estimate filtration (e.g., the established marker creatinine) or may precede and potentially contribute to CKD development. Here, we applied a nontargeted metabolomics approach using gas and liquid chromatography coupled to mass spectrometry to quantify 493 small molecules in human serum. The associations of these molecules with GFR estimated on the basis of creatinine (eGFRcr) and cystatin C levels were assessed in ≤1735 participants in the KORA F4 study, followed by replication in 1164 individuals in the TwinsUK registry. After correction for multiple testing, 54 replicated metabolites significantly associated with eGFRcr, and six of these showed pairwise correlation (r≥0.50) with established kidney function measures: C-mannosyltryptophan, pseudouridine, N-acetylalanine, erythronate, myo-inositol, and N-acetylcarnosine. Higher C-mannosyltryptophan, pseudouridine, and O-sulfo-L-tyrosine concentrations associated with incident CKD (eGFRcr

Altmetric

Weitere Metriken?

[➜Einloggen]