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Sekula, P.* ; Goek, O.N.* ; Quaye, L.* ; Barrios, C.* ; Levey, A.S.* ; Römisch-Margl, W. ; Menni, C.* ; Yet, I.* ; Gieger, C. ; Inker, L.A.* ; Adamski, J. ; Gronwald, W.* ; Illig, T. ; Dettmer, K.* ; Krumsiek, J. ; Oefner, P.J.* ; Valdes, A.M.* ; Meisinger, C. ; Coresh, J.* ; Spector, T.D.* ; Mohney, R.P.* ; Suhre, K. ; Kastenmüller, G. ; Köttgen, A.*

A metabolome-wide association study of kidney function and disease in the general population.

J. Am. Soc. Nephrol. 27, 1175-1188 (2016)
Verlagsversion DOI PMC
Open Access Gold
Small molecules are extensively metabolized and cleared by the kidney. Changes in serum metabolite concentrations may result from impaired kidney function and can be used to estimate filtration (e.g., the established marker creatinine) or may precede and potentially contribute to CKD development. Here, we applied a nontargeted metabolomics approach using gas and liquid chromatography coupled to mass spectrometry to quantify 493 small molecules in human serum. The associations of these molecules with GFR estimated on the basis of creatinine (eGFRcr) and cystatin C levels were assessed in ≤1735 participants in the KORA F4 study, followed by replication in 1164 individuals in the TwinsUK registry. After correction for multiple testing, 54 replicated metabolites significantly associated with eGFRcr, and six of these showed pairwise correlation (r≥0.50) with established kidney function measures: C-mannosyltryptophan, pseudouridine, N-acetylalanine, erythronate, myo-inositol, and N-acetylcarnosine. Higher C-mannosyltryptophan, pseudouridine, and O-sulfo-L-tyrosine concentrations associated with incident CKD (eGFRcr
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Ckd ; Epidemiology ; Gfr ; Metabolism ; Outcomes; Glomerular-filtration-rate; Protein C-mannosylation; Serum Creatinine; Transaldolase Deficiency; Uremic Patients; Renal-function; Genome-wide; Cystatin C; Pseudouridine; Accumulation
Sprache englisch
Veröffentlichungsjahr 2016
Prepublished im Jahr 2015
HGF-Berichtsjahr 2015
ISSN (print) / ISBN 1046-6673
e-ISSN 1533-3450
Zeitschrift Journal of the American Society of Nephrology
Quellenangaben Band: 27, Heft: 4, Seiten: 1175-1188 Artikelnummer: , Supplement: ,
Verlag American Society of Nephrology
Verlagsort Washington
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Bioinformatics and Systems Biology (IBIS)
Institute of Epidemiology (EPI)
Institute of Experimental Genetics (IEG)
Institute of Computational Biology (ICB)
Molekulare Endokrinologie und Metabolismus (MEM)
POF Topic(s) 30505 - New Technologies for Biomedical Discoveries
30202 - Environmental Health
90000 - German Center for Diabetes Research
30205 - Bioengineering and Digital Health
30503 - Chronic Diseases of the Lung and Allergies
30201 - Metabolic Health
Forschungsfeld(er) Enabling and Novel Technologies
Genetics and Epidemiology
PSP-Element(e) G-503700-001
G-504091-004
G-501900-061
G-503800-001
G-503900-001
G-504000-006
G-504000-002
G-505600-003
G-501900-402
G-554100-001
G-504090-001
DOI 10.1681/ASN.2014111099
WOS ID WOS:000373032500023
Scopus ID 85017080584
PubMed ID 26449609
Erfassungsdatum 2015-10-12
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