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Kovac, M.* ; Blattmann, C.* ; Ribi, S.* ; Smida, J. ; Müller, N.S. ; Engert, F.* ; Castro-Giner, F.* ; Weischenfeldt, J.* ; Kovacova, M.* ; Krieg, A.* ; Andreou, D.* ; Tunn, P.U.* ; Dürr, H.R.* ; Rechl, H.P.* ; Schaser, K.D.* ; Melcher, I.* ; Burdach, S.* ; Kulozik, A.* ; Specht, K.* ; Heinimann, K.* ; Fulda, S.* ; Bielack, S.* ; Jundt, G.* ; Tomlinson, I.* ; Korbel, J.O.* ; Nathrath, M. ; Baumhoer, D.*

Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency.

Nat. Commun. 6:8940 (2015)
Verlagsversion DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Osteosarcomas are aggressive bone tumours with a high degree of genetic heterogeneity, which has historically complicated driver gene discovery. Here we sequence exomes of 31 tumours and decipher their evolutionary landscape by inferring clonality of the individual mutation events. Exome findings are interpreted in the context of mutation and SNP array data from a replication set of 92 tumours. We identify 14 genes as the main drivers, of which some were formerly unknown in the context of osteosarcoma. None of the drivers is clearly responsible for the majority of tumours and even TP53 mutations are frequently mapped into subclones. However, >80% of osteosarcomas exhibit a specific combination of single-base substitutions, LOH, or large-scale genome instability signatures characteristic of BRCA1/2-deficient tumours. Our findings imply that multiple oncogenic pathways drive chromosomal instability during osteosarcoma evolution and result in the acquisition of BRCA-like traits, which could be therapeutically exploited.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Sprache englisch
Veröffentlichungsjahr 2015
HGF-Berichtsjahr 2015
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Zeitschrift Nature Communications
Quellenangaben Band: 6, Heft: , Seiten: , Artikelnummer: 8940 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) CCG Osteosarcoma (PATH-KOS)
Institute of Radiation Biology (ISB)
Institute of Pathology (PATH)
Institute of Computational Biology (ICB)
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30202 - Environmental Health
30205 - Bioengineering and Digital Health
Forschungsfeld(er) Enabling and Novel Technologies
Radiation Sciences
PSP-Element(e) G-520800-001
G-500200-001
G-500300-001
G-503800-001
PubMed ID 26632267
DOI 10.1038/ncomms9940
WOS ID WOS:000367577800001
Scopus ID 84949267302
Erfassungsdatum 2015-12-09
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