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Handkiewicz-Junak, D.* ; Swierniak, M.* ; Rusinek, D.* ; Oczko-Wojciechowska, M.* ; Dom, G.* ; Maenhaut, C.* ; Unger, K. ; Detours, V.* ; Bogdanova, T.* ; Thomas, G.* ; Likhtarov, I.* ; Jaksik, R.* ; Kowalski, M.* ; Chmielik, E.* ; Jarzab, M.* ; Swierniak, A.* ; Jarzab, B.*

Gene signature of the post-Chernobyl papillary thyroid cancer.

Eur. J. Nucl. Med. Mol. Imaging 43, 1267-1277 (2016)
Verlagsversion Postprint DOI
Open Access Hybrid
Creative Commons Lizenzvertrag
Purpose: Following the nuclear accidents in Chernobyl and later in Fukushima, the nuclear community has been faced with important issues concerning how to search for and diagnose biological consequences of low-dose internal radiation contamination. Although after the Chernobyl accident an increase in childhood papillary thyroid cancer (PTC) was observed, it is still not clear whether the molecular biology of PTCs associated with low-dose radiation exposure differs from that of sporadic PTC. Methods: We investigated tissue samples from 65 children/young adults with PTC using DNA microarray (Affymetrix, Human Genome U133 2.0 Plus) with the aim of identifying molecular differences between radiation-induced (exposed to Chernobyl radiation, ECR) and sporadic PTC. All participants were resident in the same region so that confounding factors related to genetics or environment were minimized. Results: There were small but significant differences in the gene expression profiles between ECR and non-ECR PTC (global test, p < 0.01), with 300 differently expressed probe sets (p < 0.001) corresponding to 239 genes. Multifactorial analysis of variance showed that besides radiation exposure history, the BRAF mutation exhibited independent effects on the PTC expression profile; the histological subset and patient age at diagnosis had negligible effects. Ten genes (PPME1, HDAC11, SOCS7, CIC, THRA, ERBB2, PPP1R9A, HDGF, RAD51AP1, and CDK1) from the 19 investigated with quantitative RT-PCR were confirmed as being associated with radiation exposure in an independent, validation set of samples. Conclusion: Significant, but subtle, differences in gene expression in the post-Chernobyl PTC are associated with previous low-dose radiation exposure.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Adolescents ; Children ; Gene Expression ; Papillary Thyroid Cancer ; Radiation ; Transcriptome
Sprache
Veröffentlichungsjahr 2016
HGF-Berichtsjahr 2016
ISSN (print) / ISBN 1619-7070
e-ISSN 1432-105X
Zeitschrift European Journal of Nuclear Medicine and Molecular Imaging
Quellenangaben Band: 43, Heft: 7, Seiten: 1267-1277 Artikelnummer: , Supplement: ,
Verlag Springer
Begutachtungsstatus Peer reviewed
Institut(e) Translational Metabolic Oncology (IDC-TMO)
POF Topic(s) 30203 - Molecular Targets and Therapies
Forschungsfeld(er) Radiation Sciences
PSP-Element(e) G-501000-001
DOI 10.1007/s00259-015-3303-3
Scopus ID 84955310875
Erfassungsdatum 2016-02-01
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