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Estrada, H. ; Rebling, J. ; Turner, J.E. ; Razansky, D.

Broadband acoustic properties of a murine skull.

Phys. Med. Biol. 61, 1932-1946 (2016)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
It has been well recognized that the presence of a skull imposes harsh restrictions on the use of ultrasound and optoacoustic techniques in the study, treatment and modulation of the brain function. We propose a rigorous modeling and experimental methodology for estimating the insertion loss and the elastic constants of the skull over a wide range of frequencies and incidence angles. A point-source-like excitation of ultrawideband acoustic radiation was induced via the absorption of nanosecond duration laser pulses by a 20 μm diameter microsphere. The acoustic waves transmitted through the skull are recorded by a broadband, spherically focused ultrasound transducer. A coregistered pulse-echo ultrasound scan is subsequently performed to provide accurate skull geometry to be fed into an acoustic transmission model represented in an angular spectrum domain. The modeling predictions were validated by measurements taken from a glass cover-slip and ex vivo adult mouse skulls. The flexible semi-analytical formulation of the model allows for seamless extension to other transducer geometries and diverse experimental scenarios involving broadband acoustic transmission through locally flat solid structures. It is anticipated that accurate quantification and modeling of the skull transmission effects would ultimately allow for skull aberration correction in a broad variety of applications employing transcranial detection or transmission of high frequency ultrasound.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Skull Characterization ; Neuroimaging ; Ultrasound Imaging ; Optoacoustic Imaging ; Acoustic Wave Propagation In Solids ; Photoacoustics; Ultrasound; Transmission; Bone; Attenuation; Absorption; Delivery; Fields; Speed; Waves; Sound
ISSN (print) / ISBN 0031-9155
e-ISSN 1361-6560
Zeitschrift Physics in Medicine and Biology
Quellenangaben Band: 61, Heft: 5, Seiten: 1932-1946 Artikelnummer: , Supplement: ,
Verlag Institute of Physics Publishing (IOP)
Verlagsort Bristol
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biological and Medical Imaging (IBMI)