PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Santenard, A.* ; Torres-Padilla, M.E.*

Epigenetic reprogramming in mammalian reproduction: Contribution from histone variants.

Epigenetics 4, 80-84 (2009)
DOI PMC
Open Access Gold möglich sobald Verlagsversion bei der ZB eingereicht worden ist.
Development of the mammalian embryo is, by definition, epigenetic. At the level of the nucleosome, the building block of the chromatin, changes in chromatin structure can be regulated through histone content. Apart from the canonical histones whose synthesis is restricted to S-phase, different histone variants have been identified. Histone variants can help to establish specialised chromatin regions and to regulate developmental and cell differentiation processes. While the role of histone variants has been extensively explored in differentiated cells, less is known in germ cells and embryos. Increasing lines of evidence suggest that the functions and/or properties of histone variants in embryos might be different to those in somatic cells. During reprogramming, histone variants such as H3.3 or H2A.Z are candidates to play potential important roles. We suggest that H3.3 has an important role in setting up a 'transition' signature, and provides the possibility to infer changes in chromatin architecture independent of DNA replication. This should confer flexibility during important developmental processes. The specific pathways through which H3.3 could regulate different chromatin conformations at different loci and the identification of specific proteins responsible for this deposition are an important challenge for future investigation. Lastly, the set of variants incorporated within the nucleosome can have important consequences in the regulation of epigenetic mechanisms during development.
Impact Factor
Scopus SNIP
Altmetric
0.000
0.420
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Sprache englisch
Veröffentlichungsjahr 2009
HGF-Berichtsjahr 0
ISSN (print) / ISBN 1559-2294
e-ISSN 1559-2308
Zeitschrift Epigenetics
Quellenangaben Band: 4, Heft: 2, Seiten: 80-84 Artikelnummer: , Supplement: ,
Verlag Landes Bioscience
Verlagsort Austin, Tex.
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epigenetics and Stem Cells (IES)
POF Topic(s) 30204 - Cell Programming and Repair
Forschungsfeld(er) Stem Cell and Neuroscience
PSP-Element(e) G-506200-001
PubMed ID 19242119
DOI 10.4161/epi.4.2.7838
Erfassungsdatum 2009-12-31
[➜Korrektur melden]