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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
FRET-based and other fluorescent proteinase probes.
Biotechnol. J. 9, 266-281 (2014)
The continuous detection of enzyme activities and their application in medical diagnostics is one of the challenges in the translational sciences. Proteinases represent one of the largest groups of enzymes in the human genome and many diseases are based on malfunctions of proteolytic activity. Fluorescent sensors may shed light on regular and irregular proteinase activity in vitro and in vivo and provide a deeper insight into the function of these enzymes and their role in pathophysiological processes. The focus of this review is on Förster resonance energy transfer (FRET)-based proteinase sensors and reporters because these probes are most likely to provide quantitative data. The medical relevance of proteinases are discussed using lung diseases as a prominent example. Probe design and probe targeting are described and fluorescent probe development for disease-relevant proteinases, including matrix-metalloproteinases, cathepsins, caspases, and other selected proteinases, is reviewed.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
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Cited By
Altmetric
0.000
1.096
18
40
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Activity-based Probes ; Cathepsins ; Cell Targeting ; Chronic Inflammatory Lung Disease ; Matrix Metalloproteinases
Sprache
englisch
Veröffentlichungsjahr
2014
HGF-Berichtsjahr
0
ISSN (print) / ISBN
1860-6768
Zeitschrift
Biotechnology Journal
Quellenangaben
Band: 9,
Heft: 2,
Seiten: 266-281
Verlag
Wiley
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Medicinal Chemistry (IMC)
POF Topic(s)
30203 - Molecular Targets and Therapies
Forschungsfeld(er)
Enabling and Novel Technologies
PSP-Element(e)
G-506300-001
PubMed ID
24464820
Erfassungsdatum
2014-09-09