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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Multifunctional LUV liposomes decorated for BBB and amyloid targeting. A. In vitro proof-of-concept.
Eur. J. Pharm. Sci. 101, 140-148 (2017)
Multifunctional LUV liposomes (mf-LIPs) were developed, having a curcumin-lipid ligand (TREG) with affinity towards amyloid species, together with ligands to target the transferrin and the LDL receptors of the blood-brain-barrier (BBB), on their surface. mf-LIPs were evaluated for their brain targeting, on hCMEC/D3 monolayers, and for their ability to inhibit Aβ-peptide aggregation. The transport of mf-LIP across hCMEC/D3 monolayers was similar to that of BBB-LIPs, indicating that the presence of TREG on their surface does not reduce their brain targeting potential. Likewise, mf-LIP inhibitory effect on Aβ aggregation was similar to that of LIPs functionalized only with TREG, proving that the presence of brain targeting ligands does not reduce the functionality of the amyloid-specific ligand. Addition of the curcumin-lipid in some liposome types was found to enhance their integrity and reduce the effect of serum proteins on their interaction with brain endothelial cells. Finally, preliminary in vivo results confirm the in vitro findings. Concluding, the current results reveal the potential of the specific curcumin-lipid derivative as a component of multifunctional LIPs with efficient brain targeting capability, intended to act as a theragnostic system for AD.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Brain ; Curcumin ; Liposomes ; Nanoparticle ; Targeting; Blood-brain-barrier; Drug-delivery Systems; Alzheimers-disease; High-affinity; Beta Peptide; Nanoliposomes; Nanoparticles; Ligand; Aggregation; Transferrin
ISSN (print) / ISBN
0928-0987
e-ISSN
0928-0987
Zeitschrift
European Journal of Pharmaceutical Sciences
Quellenangaben
Band: 101,
Seiten: 140-148
Verlag
Elsevier
Verlagsort
Amsterdam
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Lung Health and Immunity (LHI)