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Hockman, D.* ; Burns, A.* ; Schlosser, G.* ; Gates, K.P.* ; Jevans, B.* ; Mongera, A.* ; Fisher, S.* ; Unlu, G.* ; Knapik, E.W.* ; Kaufman, C.K.* ; Mosimann, C.* ; Zon, L.I.* ; Lancman, J.J.* ; Dong, P.D.* ; Lickert, H. ; Tucker, A.S.* ; Baker, C.V.*

Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes.

eLife 6:e21231 (2017)

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The evolutionary origins of the hypoxia-sensitive cells that trigger amniote respiratory reflexes - carotid body glomus cells, and 'pulmonary neuroendocrine cells' (PNECs) - are obscure. Homology has been proposed between glomus cells, which are neural crest-derived, and the hypoxia-sensitive 'neuroepithelial cells' (NECs) of fish gills, whose embryonic origin is unknown. NECs have also been likened to PNECs, which differentiate in situ within lung airway epithelia. Using genetic lineage-tracing and neural crest-deficient mutants in zebrafish, and physical fate-mapping in frog and lamprey, we find that NECs are not neural crest-derived, but endoderm-derived, like PNECs, whose endodermal origin we confirm. We discover neural crest-derived catecholaminergic cells associated with zebrafish pharyngeal arch blood vessels, and propose a new model for amniote hypoxia-sensitive cell evolution: endoderm-derived NECs were retained as PNECs, while the carotid body evolved via the aggregation of neural crest-derived catecholaminergic (chromaffin) cells already associated with blood vessels in anamniote pharyngeal arches.

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