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Sharma, S. ; Kriebel, J. ; Grallert, H.

Epigenetic regulation of glucose metabolism.

Curr. Opin. Clin. Nutr. Metab. Care 20, 266-271 (2017)
Verlagsversion DOI PMC
Open Access Gold
PURPOSE OF REVIEW: Glucose metabolism is a central process in mammalian energy homeostasis. Its deregulation is a key factor in development of metabolic disease like diabetes and cancer. In recent decades, our understanding of gene regulation at the signaling, chromatin and posttranscriptional levels has seen dramatic developments. RECENT FINDINGS: A number of epigenetic mechanisms that do not affect the genetic code can be assessed with new technologies. However, increasing complexity becomes a major challenge for translation into clinical application. SUMMARY: The current review provides an update of transcriptional control of glucose metabolism, focusing on epigenetic regulators, DNA-methylation, histone modifications and noncoding RNAs. Recent studies heavily support the importance of those mechanisms for future therapeutics and preventive efforts for metabolic diseases.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Dna Methylation ; Epigenetics ; Glucose Metabolism ; Histone Modification ; Noncoding Rna; Epigenome-wide Association; Type-2 Diabetes-mellitus; Long Noncoding Rna; Dna Methylation; Maternal Hyperglycemia; Insulin-resistance; Peripheral-blood; Glycemic Traits; Susceptibility; Identification
Sprache englisch
Veröffentlichungsjahr 2017
HGF-Berichtsjahr 2017
ISSN (print) / ISBN 1363-1950
e-ISSN 1473-6519
Zeitschrift Current Opinion in Clinical Nutrition & Metabolic Care
Quellenangaben Band: 20, Heft: 4, Seiten: 266-271 Artikelnummer: , Supplement: ,
Verlag Lippincott Williams & Wilkins
Verlagsort Philadelphia
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
POF Topic(s) 30202 - Environmental Health
90000 - German Center for Diabetes Research
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504091-002
G-501900-402
DOI 10.1097/MCO.0000000000000375
WOS ID WOS:000402543300007
Scopus ID 85018678018
PubMed ID 28441146
Erfassungsdatum 2017-07-03
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