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Le Thuc, O. ; Stobbe, K.* ; Cansell, C.* ; Nahon, J.L.* ; Blondeau, N.* ; Rovère, C.*

Hypothalamic inflammation and energy balance disruptions: Spotlight on chemokines.

Front. Endocrin. 8:197 (2017)
Verlagsversion DOI
Open Access Gold
Creative Commons Lizenzvertrag
The hypothalamus is a key brain region in the regulation of energy balance as it controls food intake and both energy storage and expenditure through integration of humoral, neural, and nutrient-related signals and cues. Many years of research have focused on the regulation of energy balance by hypothalamic neurons, but the most recent findings suggest that neurons and glial cells, such as microglia and astrocytes, in the hypothalamus actually orchestrate together several metabolic functions. Because glial cells have been described as mediators of inflammatory processes in the brain, the existence of a causal link between hypothalamic inflammation and the deregulations of feeding behavior, leading to involuntary weight loss or obesity for example, has been suggested. Several inflammatory pathways that could impair the hypothalamic control of energy balance have been studied over the years such as, among others, toll-like receptors and canonical cytokines. Yet, less studied so far, chemokines also represent interesting candidates that could link the aforementioned pathways and the activity of hypothalamic neurons. Indeed, chemokines, in addition to their role in attracting immune cells to the inflamed site, have been suggested to be capable of neuromodulation. Thus, they could disrupt cellular activity together with synthesis and/or secretion of multiple neurotransmitters/mediators involved in the maintenance of energy balance. This review discusses the different inflammatory pathways that have been identified so far in the hypothalamus in the context of feeding behavior and body weight control impairments, with a particular focus on chemokines signaling that opens a new avenue in the understanding of the major role played by inflammation in obesity.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Anorexia ; Chemokines ; Energy Balance ; High-fat Diet ; Hypothalamus ; Metabolic Diseases ; Neuroinflammation ; Obesity; High-fat Diet; Endoplasmic-reticulum Stress; Beta/nf-kappa-b; Melanin-concentrating Hormone; Cell-derived Factor-1-alpha; Induced Insulin-resistance; Central-nervous-system; Necrosis-factor-alpha; Induced Anorexia; Sickness Behavior
Sprache englisch
Veröffentlichungsjahr 2017
HGF-Berichtsjahr 2017
ISSN (print) / ISBN 1664-2392
e-ISSN 1664-2392
Zeitschrift Frontiers in Endocrinology
Quellenangaben Band: 8, Heft: AUG, Seiten: , Artikelnummer: 197 Supplement: ,
Verlag Frontiers
Verlagsort Lausanne
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Obesity (IDO)
POF Topic(s) 30201 - Metabolic Health
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502200-001
DOI 10.3389/fendo.2017.00197
WOS ID WOS:000408496600001
Scopus ID 85027728639
Erfassungsdatum 2017-09-05
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