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Kullmann, S.
;
Veit, R.
;
Peter, A.
; Pohmann, R.* ; Scheffler, K.* ;
Häring, H.-U.
;
Fritsche, A.
;
Preissl, H.
;
Heni, M.
Dose-dependent effects of intranasal insulin on resting-state brain activity.
J. Clin. Endocrinol. Metab.
103
, 253-262 (2017)
Verlagsversion
DOI
PMC
Free by publisher
Open Access Green
möglich sobald Postprint bei der ZB eingereicht worden ist.
Abstract
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Zusatzinfos
© 2018 Endocrine Society. Context: Insulin action in the human brain influences eating behavior, cognition, and whole-body metabolism. Studies investigating brain insulin rely on intranasal application. Objective: To investigate effects of three doses of insulin and placebo as nasal sprays on the central and autonomous nervous system and analyze absorption of insulin into the bloodstream. Design, Participants, and Methods: Nine healthy men received placebo or 40 U, 80 U, and 160 U insulin spray in randomized order. Before and after spray, brain activity was assessed by functional magnetic resonance imaging, and heart rate variability (HRV) was assessed from electrocardiogram. Plasma insulin, C-peptide, and glucose were measured regularly. Setting: General community. Results: Nasal insulin administration dose-dependently modulated regional brain activity and the normalized high-frequency component of the HRV. Post hoc analyses revealed that only 160 U insulin showed a considerable difference from placebo. Dose-dependent spillover of nasal insulin into the bloodstream was detected. The brain response was not correlated with this temporary rise in circulating insulin. Conclusions: Nasal insulin dose-dependently modulated regional brain activity with the strongest effects after 160 U. However, this dose was accompanied by a transient increase in circulating insulin concentrations due to a spillover into circulation. Our current results may serve as a basis for future studies with nasal insulin to untangle brain insulin effects in health and disease.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Typ der Hochschulschrift
Herausgeber
Korrespondenzautor
Schlagwörter
Endogenous Glucose-production; Central-nervous-system; Food-intake; Humans; Memory; Men; Sensitivity; Resistance; Hypothalamus; Metabolism
Keywords plus
ISSN (print) / ISBN
0021-972X
e-ISSN
1945-7197
ISBN
Bandtitel
Konferenztitel
Konferzenzdatum
Konferenzort
Konferenzband
Zeitschrift
Journal of Clinical Endocrinology & Metabolism, The
Quellenangaben
Band: 103,
Heft: 1,
Seiten: 253-262
Artikelnummer: ,
Supplement: ,
Reihe
Verlag
Endocrine Society
Verlagsort
Bethesda, Md.
Hochschule
Hochschulort
Fakultät
Veröffentlichungsdatum
0000-00-00
Veröffentlichungsnummer
Anmeldedatum
0000-00-00
Anmelder/Inhaber
weitere Inhaber
Anmeldeland
Priorität
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Diabetes Research and Metabolic Diseases (IDM)
Förderungen
Copyright