PuSH - Publikationsserver des Helmholtz Zentrums München: Association of maternal prenatal smoking GFI1-locus and cardiometabolic phenotypes in 18,212 adults.

Informationen

Hinweise zu Qualitätskriterien von Zeitschriften

Open-Access-Richtlinie der Helmholtz-Gemeinschaft 2016

CC Licencences

Metriken für Publikationen

Navigation

Startseite

English

EVA: Veröffentlichen

Neuer EVA Antrag

Recherche

Erweiterte Suche

Durchblättern nach ...

... HMGU-Autoren/Konsortien

... Organisationsstruktur

... Zeitschriften

... Publikationstypen

... Forschungsdaten

... Arbeitsgruppen

... Erscheinungsjahr

Publikationen im Überblick

Statistik

HGF Fortschrittsbericht

OA Publikationen

Eintragen

Neue Publikation eintragen

Neue Publikation holen aus...

...EVA

Fehlende Publikation melden

Highlights

Suche

Hilfe & Kontakt

Ansprechpartner

Hilfe

Datenschutz

Helmholtz Open Science

Bibliometrische Indikatoren

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Parmar, P.* ; Lowry, E.* ; Cugliari, G.* ; Suderman, M.* ; Wilson, R. ; Karhunen, V.* ; Andrew, T.* ; Wiklund, P.* ; Wielscher, M.* ; Guarrera, S.* ; Teumer, A.* ; Lehne, B.* ; Milani, L.* ; de Klein, N.* ; Mishra, P.P.* ; Melton, P.E.* ; Mandaviya, P.R.* ; Kasela, S.* ; Nano, J. ; Zhang, W.* ; Zhang, Y.* ; Uitterlinden, A.G.* ; Peters, A. ; Schöttker, B.* ; Gieger, C. ; Anderson, D.* ; Boomsma, D.I.* ; Grabe, H.J.* ; Panico, S.* ; Veldink, J.H.* ; van Meurs, J.B.J.* ; van den Berg, L.H.* ; Beilin, L.J.* ; Franke, L.* ; Loh, M.* ; Van Greevenbroek, M.M.J.* ; Nauck, M.* ; Kähönen, M.* ; Li, S.* ; Chambers, J.C.* ; Sebert, S.* ; Slagboom, P.E.* ; van der Harst, P.* ; Kunze, S. ; Felix, S.B.* ; Zhang, T.* ; Chen, W.* ; Mori, T.A.* ; Bonnefond, A.* ; Heijmans, B.T.* ; Muka, T.* ; Kooner, J.S.* ; Fischer, K.* ; Waldenberger, M. ; Froguel, P.* ; Huang, R.-C.* ; Lehtimäki, T.* ; Rathmann, W.* ; Relton, C.L.* ; Matullo, G.* ; Brenner, H.* ; Verweij, N.* ; Järvelin, M.-R.*

Association of maternal prenatal smoking GFI1-locus and cardiometabolic phenotypes in 18,212 adults.

EBioMedicine 38, 206-216 (2018)

Verlagsversion

DOI

PMC

	Open Access Gold

Abstract
Metriken
Zusatzinfos

Background: DNA methylation at the GFI1-locus has been repeatedly associated with exposure to smoking from the foetal period onwards. We explored whether DNA methylation may be a mechanism that links exposure to maternal prenatal smoking with offspring's adult cardio-metabolic health.Methods: We meta-analysed the association between DNA methylation at GFI1-locus with maternal prenatal smoking, adult own smoking, and cardio-metabolic phenotypes in 22 population-based studies from Europe, Australia, and USA (n= 18,212). DNA methylation at the GFI1-locus was measured in whole-blood. Multivariable regression models were fitted to examine its association with exposure to prenatal and own adult smoking. DNA methylation levels were analysed in relation to body mass index (BMI), waist circumference (WC), fasting glucose (FG), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), diastolic, and systolic blood pressure (BP).Findings: Lower DNA methylation at three out of eight GFI1-CpGs was associated with exposure to maternal prenatal smoking, whereas, all eight CpGs were associated with adult own smoking. Lower DNA methylation at cg14179389, the strongest maternal prenatal smoking locus, was associated with increased WC and BP when adjusted for sex, age, and adult smoking with Bonferroni-corrected P < 0.012. In contrast, lower DNA methylation at cg09935388, the strongest adult own smoking locus, was associated with decreased BMI, WC, and BP (adjusted 1 x 10(-7) < P < 0.01). Similarly, lower DNA methylation at cg12876356, cg18316974, cg09662411, and cg18146737 was associated with decreased BMI and WC (5 x 10(-8) < P < 0.001). Lower DNA methylation at all the CpGs was consistently associated with higher TG levels.Interpretation: Epigenetic changes at the GFI1 were linked to smoking exposure in-utero/in-adulthood and robustly associated with cardio-metabolic risk factors. Fund: European Union's Horizon 2020 research and innovation programme under grant agreement no. 633595 DynaHEALTH. (c) 2018 The Authors. Published by Elsevier B.V.

Impact Factor

Scopus SNIP

Web of Science
Times Cited

Scopus
Cited By

Altmetric

6.183

1.275