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Jeremias, I. ; Schewe, D.M.*

Characteristics and therapeutic targeting of minimal residual disease in childhood acute lymphoblastic leukemia.

Adv. Exp. Med. Biol. 1100, 127-139 (2018)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Early response to therapy, especially the measurement of minimal residual disease (MRD), remains the most reliable and strongest independent prognostic parameter. Intriguingly, little is known on the mechanisms sustaining MRD in that disease. Here, we summarize existing evidence on the influences of molecular genetics and clonal architecture of childhood ALL on disease persistence. Also, the impact of the leukemic niche on residual leukemia cells in the bone marrow and extramedullary compartments is reviewed. We further discuss existing in vivo models of minimal residual disease based on different cellular labelling strategies and engraftment of ALL cells in immunodeficient mouse strains. We finally draw some conclusions on potential strategies targeting residual ALL cells, with a focus on cellular and antibodybased immunotherapy.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Acute Lymphoblastic Leukemia ; Childhood Leukemia ; B-cell Precursor ; Mrd ; Dormancy ; Mesenchymal Stem Cells ; Quiescent Cells ; Xenograft Models ; Immunodeficient Mice; Central-nervous-system; Relapse-free Survival; Car T-cells; Propagating Cells; Genomic Landscape; Cns Infiltration; Stem-cells; Aieop-bfm; B-all; Precursor
Sprache englisch
Veröffentlichungsjahr 2018
HGF-Berichtsjahr 2018
ISSN (print) / ISBN 0065-2598
Zeitschrift Advances in Experimental Medicine and Biology
Quellenangaben Band: 1100, Heft: , Seiten: 127-139 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort New York
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Apoptosis in Hematopoietic Stem Cells (AHS)
POF Topic(s) 30204 - Cell Programming and Repair
Forschungsfeld(er) Stem Cell and Neuroscience
PSP-Element(e) G-506600-001
DOI 10.1007/978-3-319-97746-1_8
WOS ID WOS:000457972100009
Scopus ID 85056431726
PubMed ID 30411264
Erfassungsdatum 2018-12-05
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