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Schleger, F. ; Linder, K. ; Walter, L.* ; Heni, M. ; Braendle, J.* ; Brucker, S.* ; Pauluschke-Froehlich, J.* ; Weiss, M.* ; Häring, H.-U. ; Preissl, H. ; Fritsche, A.

Family history of diabetes is associated with delayed fetal postprandial brain activity.

Front. Endocrin. 9:673 (2018)
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Introduction: We have previously shown that fetuses of mothers with gestational diabetes mellitus (GDM) and insulin resistance exhibit a prolongation of fetal auditory event-related brain responses (fAER) compared to fetuses of normal glucose tolerant women during an oral glucose tolerance test (oGTT). This implies that maternal metabolism may program the developing fetal brain. We now asked whether a family history of type 2 diabetes without metabolic programing also impacts fetal brain activity. We therefore investigated brain activity in fetuses of normal glucose tolerant mothers with and without family history of type 2 diabetes (FHD+ and FHD-).Methods: A 75 g oGTT was performed in healthy pregnant women. Plasma glucose and insulin levels were measured after 0, 60, and 120 min. Each blood draw was preceded by fetal magnetoencephalographic (fMEG) recordings of fAER. From a group of 167 participants, a subsample of 52 metabolically healthy women, 37 with a negative, and 15 with a positive FHD (at least one first- or second-degree relative) was carefully selected based on the following inclusion criteria: inconspicuous pregnancy, no GDM, BMI 18.5-30 kg/m(2), no preterm birth and at least two fMEG with detectable fetal responses during oGTT.Results: An ANOVA showed a significant interaction between fMEG measurement time during the oGTT and FHD on fAER latency [F-(2) = 4.163, p = 0.018]. Fetuses of mothers with FHD+ had a prolonged fAER (273 +/- 113 ms) compared to fetuses of mothers with FHD- (219 +/- 69 ms) at 60 min during the oGTT [F-(1() )= 4.902, p = 0.032]. There were no significant differences in age, BMI before pregnancy, weight gain during pregnancy and gestational age between the groups. Maternal glucose levels and insulin sensitivity were also not significantly different.Discussion: In addition to the previously shown influence of maternal metabolism on fetal brain activity, maternal family history of diabetes (FHD) is also linked to fetal postprandial brain activity. This indicates that genetic and/or epigenetic factors modulate the postprandial brain response of the developing fetus.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Fetal Meg ; Ogtt ; Family History ; Type 2 Diabetes ; Maternal Metabolism ; Fetal Programming; Insulin-resistance; In-utero; Magnetoencephalography; Multicenter; Obesity
Sprache englisch
Veröffentlichungsjahr 2018
HGF-Berichtsjahr 2018
ISSN (print) / ISBN 1664-2392
e-ISSN 1664-2392
Zeitschrift Frontiers in Endocrinology
Quellenangaben Band: 9, Heft: , Seiten: , Artikelnummer: 673 Supplement: ,
Verlag Frontiers
Verlagsort Lausanne
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)
Institute of Diabetes and Obesity (IDO)
POF Topic(s) 90000 - German Center for Diabetes Research
30201 - Metabolic Health
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502400-001
G-502200-001
DOI 10.3389/fendo.2018.00673
WOS ID WOS:000450701300001
Erfassungsdatum 2018-12-03
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