PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Meyer, J.* ; Eley, J.* ; Schmid, T.E. ; Combs, S.E. ; Dendale, R.* ; Prezado, Y.*

Spatially fractionated proton minibeams.

Br. J. Radiol. 91:20180466 (2019)
Verlagsversion DOI PMC
Closed
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Extraordinary normal tissue response to highly spatially fractionated X-ray beams has been explored for over 25 years. More recently, alternative radiation sources have been developed and utilized with the aim to evoke comparable effects. These include protons, which lend themselves well for this endeavour due to their physical depth dose characteristics as well as corresponding variable biological effectiveness. This paper addresses the motivation for using protons to generate spatially fractionated beams and reviews the technological implementations and experimental results to date. This includes simulation and feasibility studies, collimation and beam characteristics, dosimetry and biological considerations as well as the results of in vivo and in vitro studies. Experimental results are emerging indicating an extraordinary normal tissue sparing effect analogous to what has been observed for synchrotron generated X-ray microbeams. The potential for translational research and feasibility of spatially modulated proton beams in clinical settings is discussed.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
1.939
0.928
14
16
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Equivalent Uniform Dose ; Microbeam Radiotherapy ; Normal Tissue Sparing ; Relative Biological Effectiveness ; Spatially Fractionated Radiation Therapy; Microbeam Radiation-therapy; Glioma-bearing Rats; Microplanar Beams; 9l Gliosarcoma; Spinal-cord; Synchrotron; Brain; Radiotherapy; Irradiation; Skin
Sprache englisch
Veröffentlichungsjahr 2019
Prepublished im Jahr 2018
HGF-Berichtsjahr 2018
ISSN (print) / ISBN 0007-1285
e-ISSN 1748-880X
Zeitschrift British Journal of Radiology, The
Quellenangaben Band: 91, Heft: 1095, Seiten: , Artikelnummer: 20180466 Supplement: ,
Verlag British Institute of Radiology N.S
Verlagsort 36 Portland Place, London W1n 4at, England
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Radiation Medicine (IRM)
POF Topic(s) 30203 - Molecular Targets and Therapies
Forschungsfeld(er) Radiation Sciences
PSP-Element(e) G-501300-001
DOI 10.1259/bjr.20180466
WOS ID WOS:000459432000013
Scopus ID 85061991257
PubMed ID 30359081
Erfassungsdatum 2018-12-13
[➜Korrektur melden]