PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Singh, S.P.* ; Ninov, N.

The triumvirate of beta-cell regeneration: Solutions and bottlenecks to curing diabetes.

Int. J. Dev. Biol. 62, 453-464 (2018)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
On 11 January 1922 insulin injection was used for the first time in the treatment of diabetes. Even today, daily insulin injections are the life-saving treatment for patients with Type 1 diabetes and advanced Type 2 diabetes. However, insulin injections often fail to achieve full glucose control, which in the long-term leads to multiple complications and mortality. Beta-cells, the natural producers and secretors of insulin, remain the gold-standard in regulating blood glucose levels. In this review, we focus on three strategies aiming at counteracting beta-cell loss in order to gain insulin independence: replacement, replication and protection. The three approaches, together termed as the triumvirate of beta-cell regeneration, may constitute the basis for a future cure for diabetes.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
1.579
0.657
3
4
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Reprogramming ; Regeneration ; Protection ; Diabetes; Insulin-producing Cells; In-vivo; Centroacinar Cells; Secreting Cells; Stem-cells; Mass; Endocrine; Islets; Liver; Differentiation
Sprache englisch
Veröffentlichungsjahr 2018
HGF-Berichtsjahr 2018
ISSN (print) / ISBN 0214-6282
e-ISSN 1696-3547
Zeitschrift International Journal of Developmental Biology
Quellenangaben Band: 62, Heft: 6-8, Seiten: 453-464 Artikelnummer: , Supplement: ,
Verlag University of the Basque Country Press (UBC Press)
Verlagsort Po Box 1397, Bilbao, Bizkaia E-48080, Spain
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Pancreatic Islet Research (IPI)
POF Topic(s) 90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502600-010
DOI 10.1387/ijdb.180067nn
WOS ID WOS:000451691600013
Erfassungsdatum 2018-12-20
[➜Korrektur melden]