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Dang, K.M.* ; Rinklin, P.* ; Afanasenkau, D.* ; Westmeyer, G.G. ; Schürholz, T.* ; Wiegand, S.* ; Wolfrum, B.*

Chip-based heat stimulation for modulating signal propagation in HL-1 cell networks.

Adv. Biosyst. 2:1800138 (2018)

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Signal propagation in cardiac cell networks can be modulated by heat stimulation. Here, the response of a connected HL-1 cardiomyocyte cell network to the application of confined heat stimuli using Ca 2+ imaging is investigated. Localized temperature gradients are generated by resistive heating via microwire arrays on a chip surface, which serves as a substrate for growing a confluent cell network. It is demonstrated that upon heat stimulation, the velocity of the propagating Ca 2+ wave in the network is locally increased, leading to a deformation of the wavefront. Furthermore, evidence of a change in the signal propagation direction caused by a relocation of the pacemaker cell is shown. This effect might be used in future applications, where heat is employed as an alternative modality for cell stimulation protocols.

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