PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Lämmermann, I.* ; Terlecki-Zaniewicz, L.* ; Weinmüllner, R.* ; Schosserer, M.* ; Dellago, H.* ; de Matos Branco, A.D.* ; Autheried, D.* ; Sevcnikar, B.* ; Kleissl, L.* ; Berlin, I.* ; Morizot, F.* ; Lejeune, F.* ; Fuzzati, N.* ; Forestier, S.* ; Toribio, A.* ; Tromeur, A.* ; Weinberg, L.* ; Almaraz, J.C.H. ; Scheideler, M. ; Rietveld, M.* ; El Ghalbzouri, A.* ; Tschachler, E.* ; Gruber, F.* ; Grillari, J.*

Blocking negative effects of senescence in human skin fibroblasts with a plant extract.

npj Aging Mech. Dis. 4:4 (2018)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
There is increasing evidence that senescent cells are a driving force behind many age-related pathologies and that their selective elimination increases the life- and healthspan of mice. Senescent cells negatively affect their surrounding tissue by losing their cell specific functionality and by secreting a pro-tumorigenic and pro-inflammatory mixture of growth hormones, chemokines, cytokines and proteases, termed the senescence-associated secretory phenotype (SASP). Here we identified an extract from the plant subsp. , which exhibited weak senolytic activity, delayed the acquisition of a senescent phenotype and induced a papillary phenotype with improved functionality in human dermal fibroblasts. When administered to stress-induced premature senescent fibroblasts, this extract changed their global mRNA expression profile and particularly reduced the expression of various SASP components, thereby ameliorating the negative influence on nearby cells. Thus, the investigated plant extract represents a promising possibility to block age-related loss of tissue functionality.
Impact Factor
Scopus SNIP
Scopus
Cited By
Altmetric
0.000
0.000
26
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Sprache englisch
Veröffentlichungsjahr 2018
HGF-Berichtsjahr 2018
ISSN (print) / ISBN 2056-3973
e-ISSN 2056-3973
Zeitschrift npj Aging and Mechanisms of Disease
Quellenangaben Band: 4 Heft: , Seiten: , Artikelnummer: 4 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London [u.a.]
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Cancer (IDC)
POF Topic(s) 90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-501900-252
DOI 10.1038/s41514-018-0023-5
PubMed ID 29675264
Erfassungsdatum 2019-01-28
[➜Korrektur melden]