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Camargo Ortega, G. ; Falk, S. ; Johansson, P.A. ; Peyre, E.* ; Broix, L.* ; Sahu, S.K.* ; Hirst, W.* ; Schlichthaerle, T.* ; de Juan Romero, C.* ; Draganova, K. ; Vinopal, S.* ; Chinnappa, K. ; Gavranovic, A. ; Karakaya, T. ; Steininger, T. ; Merl-Pham, J. ; Feederle, R. ; Shao, W.* ; Shi, S.H.* ; Hauck, S.M. ; Jungmann, R.* ; Bradke, F.* ; Borrell, V.* ; Geerlof, A. ; Reber, S.* ; Tiwari, V.K.* ; Huttner, W.B.* ; Wilsch-Bräuninger, M.* ; Nguyen, L.A.* ; Götz, M.

The centrosome protein AKNA regulates neurogenesis via microtubule organization.

Nature 567, 113-117 (2019)
Postprint Forschungsdaten DOI PMC
Open Access Green
The expansion of brain size is accompanied by a relative enlargement of the subventricular zone during development. Epithelial-like neural stem cells divide in the ventricular zone at the ventricles of the embryonic brain, self-renew and generate basal progenitors(1) that delaminate and settle in the subventricular zone in enlarged brain regions(2). The length of time that cells stay in the subventricular zone is essential for controlling further amplification and fate determination. Here we show that the interphase centrosome protein AKNA has a key role in this process. AKNA localizes at the subdistal appendages of the mother centriole in specific subtypes of neural stem cells, and in almost all basal progenitors. This protein is necessary and sufficient to organize centrosomal microtubules, and promote their nucleation and growth. These features of AKNA are important for mediating the delamination process in the formation of the subventricular zone. Moreover, AKNA regulates the exit from the subventricular zone, which reveals the pivotal role of centrosomal microtubule organization in enabling cells to both enter and remain in the subventricular zone. The epithelial-to-mesenchymal transition is also regulated by AKNA in other epithelial cells, demonstrating its general importance for the control of cell delamination.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Epithelial-mesenchymal Transition; Expression; Expansion; Migration; Pathways; Cortex
Sprache englisch
Veröffentlichungsjahr 2019
HGF-Berichtsjahr 2019
ISSN (print) / ISBN 0028-0836
e-ISSN 1476-4687
Zeitschrift Nature
Quellenangaben Band: 567, Heft: 7746, Seiten: 113-117 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Stem Cell Research (ISF)
CF Metabolomics & Proteomics (CF-MPC)
CF Monoclonal Antibodies (CF-MAB)
Institute of Structural Biology (STB)
Institute of Diabetes and Obesity (IDO)
POF Topic(s) 30204 - Cell Programming and Repair
30203 - Molecular Targets and Therapies
30201 - Metabolic Health
Forschungsfeld(er) Stem Cell and Neuroscience
Enabling and Novel Technologies

Helmholtz Diabetes Center
PSP-Element(e) G-500800-001
G-505700-001
A-630700-001
G-502210-001
G-503000-001
DOI 10.1038/s41586-019-0962-4
WOS ID WOS:000460426900052
Scopus ID 85062611746
PubMed ID 30787442
Erfassungsdatum 2019-03-15
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