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Graae, A.S.* ; Grarup, N.* ; Ribel-Madsen, R.* ; Lystbæk, S.H.* ; Boesgaard, T.W.* ; Staiger, H. ; Fritsche, A. ; Wellner, N.* ; Sulek, K.* ; Kjolby, M.* ; Backe, M.B.* ; Chubanava, S.* ; Prats, C.* ; Serup, A.K.* ; Birk, J.B.* ; Dubail, J.* ; Gillberg, L.* ; Vienberg, S.G.* ; Nykjær, A.* ; Kiens, B.* ; Wojtaszewski, J.F.P.* ; Larsen, S.* ; Apte, S.S.* ; Häring, H.-U. ; Vaag, A.* ; Zethelius, B.* ; Pedersen, O.* ; Treebak, J.T.* ; Hansen, T.* ; Holst, B.*

ADAMTS9 regulates skeletal muscle insulin sensitivity through extracellular matrix alterations.

Diabetes 68, 502-514 (2019)
Verlagsversion Forschungsdaten DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The ADAMTS9 rs4607103 C allele is one of the few gene variants proposed to increase the risk of type 2 diabetes through an impairment of insulin sensitivity. We show that the variant is associated with increased expression of the secreted ADAMTS9 and decreased insulin sensitivity and signaling in human skeletal muscle. In line with this, mice lacking Adamts9 selectively in skeletal muscle have improved insulin sensitivity. The molecular link between ADAMTS9 and insulin signaling was characterized further in a model where ADAMTS9 was overexpressed in skeletal muscle. This selective over expression resulted in decreased insulin signaling presumably mediated through alterations of the integrin 131 signaling pathway and disruption of the intracellular cytoskeletal organization. Furthermore, this led to impaired mitochondria! function in mouse muscle-an observation found to be of translational character because humans carrying the ADAMTS9 risk allele have decreased expression of mitochondrial markers. Finally, we found that the link between ADAMTS9 overexpression and impaired insulin signaling could be due to accumulation of harmful lipid intermediates. Our findings contribute to the understanding of the molecular mechanisms underlying insulin resistance and type 2 diabetes and point to inhibition of ADAMTS9 as a potential novel mode of treating insulin resistance.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Focal Adhesion Kinase; Genome-wide Association; Mitochondrial-function; Resistance; Fat; Expression; Metalloprotease; Susceptibility; Secretion; Multiple
Sprache
Veröffentlichungsjahr 2019
HGF-Berichtsjahr 2019
ISSN (print) / ISBN 0012-1797
e-ISSN 1939-327X
Zeitschrift Diabetes
Quellenangaben Band: 68, Heft: 3, Seiten: 502-514 Artikelnummer: , Supplement: ,
Verlag American Diabetes Association
Verlagsort Alexandria, VA.
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)
POF Topic(s) 90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502400-001
DOI 10.2337/db18-0418
WOS ID WOS:000459677400006
Scopus ID 85061898551
PubMed ID 30626608
Erfassungsdatum 2019-03-13
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