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Harris, C. ; von Berg, A.* ; Berdel, D.* ; Bauer, C.P.* ; Schikowski, T.* ; Koletzko, S.* ; Heinrich, J. ; Schulz, H. ; Standl, M.

Dietary saturated fat and low-grade inflammation modified by accelerometer-measured physical activity in adolescence: Results from the GINIplus and LISA birth cohorts.

BMC Public Health 19:818 (2019)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
BackgroundSaturated fatty acids (SFA) have been reported to promote inflammation. Nevertheless, evidence linking dietary SFA and low-grade inflammation in adolescents is scarce and inconsistent. The modulatory role of physical activity (PA) on fat metabolism and inflammation may provide a potential explanation. Thus, we assessed the association of dietary SFA with high-sensitivity C-reactive protein (hsCRP), a marker of low-grade inflammation, in 15-year-olds, and evaluated possible interactions between dietary SFA and different levels of PA.MethodsChildren participating in the 15-year follow-ups of the GINIplus and LISA German birth cohort studies were included (N=824). SFA intake was estimated by means of a food frequency questionnaire and PA recorded by accelerometers. Average daily minutes of PA were classified into sedentary, light and moderate-to-vigorous (MVPA), using Freedson's cut-offs. HsCRP concentrations were measured in serum and categorized into 3 sex-specific levels (below detection limit (I), above 75th percentile (III), in between (II)). Sex-stratified cross-sectional associations between SFA and hsCRP were assessed using multinomial logistic regression, adjusting for potential confounders. Interaction terms were included between SFA and the different PA levels; and if significant interactions were observed, analyses stratified by tertiles of the relevant PA levels were performed. Relative risk ratios (RRR) and 95% confidence intervals (95%CI) were presented for a 1% increase in SFA.ResultsAn inverse association was observed between SFA intake and hsCRP (II vs. I) in males (RRR=0.85 [95%CI=0.76;0.96], p=0.008), whereas no significant association was observed in females. A significant interaction was observed with sedentary and light PA but not with MVPA in both sexes (p<0.05). Stratified analyses indicated a significant inverse association between SFA and medium hsCRP levels in males in the highest light PA tertile (hsCRP II vs. I: 0.67 [0.517;0.858], p=0.002).ConclusionOur findings do not support a detrimental role of dietary SFA in low-grade inflammation among adolescents. In males, higher dietary SFA was associated with lower hsCRP, although this should be interpreted in the context of possibly correlated nutrients. Children spending the most time in light PA drove the observed inverse association, suggesting a synergistic effect of SFA and lifestyle PA in the resultant inflammatory response.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Dietary Intake ; Low-grade Inflammation ; Saturated Fat ; Physical Activity ; Accelerometer ; Adolescents ; Epidemiology; C-reactive Protein; Food Frequency Questionnaire; Cardiovascular Risk-factors; Life-style; Metabolic-syndrome; Systemic Inflammation; Insulin-resistance; Blood-pressure; Children; Acids
ISSN (print) / ISBN 1471-2458
e-ISSN 1471-2458
Zeitschrift BMC Public Health
Quellenangaben Band: 19, Heft: 1, Seiten: , Artikelnummer: 818 Supplement: ,
Verlag BioMed Central
Verlagsort Campus, 4 Crinan St, London N1 9xw, England
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)