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Rabus, H.* ; Gargioni, E.* ; Li, W.B. ; Nettelbeck, H.* ; Villagrasa, C.*

Determining dose enhancement factors of high-Z nanoparticles from simulations where lateral secondary particle disequilibrium exists.

Phys. Med. Biol. 64:155016 (2019)
Verlagsversion Postprint DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Nanoparticles (NPs) containing high atomic number (high-Z) materials have been shown to enhance the radiobiological effectiveness of ionizing radiation. This effect is often attributed to an enhancement of the absorbed dose in the vicinity of the NPs, based on Monte Carlo simulations that show a significant local enhancement of the energy deposition on the microscopic scale. The results of such simulations may be significantly biased and lead to a severe overestimation of the dose enhancement if the condition of secondary particle equilibrium is not met in the simulation setup. This current work shows an approach to estimate a 'realistic' dose enhancement from the results of such biased simulations which is based on published photon interaction data and provides a way for correcting biased results.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Dose Enhancement ; Gold Nanoparticles ; High-z Nanoparticles ; Monte Carlo Simulation ; Secondary Electron Equilibrium; Monte-carlo-simulation; Gold Nanoparticles; Radiation; Radiotherapy; Brachytherapy
ISSN (print) / ISBN 0031-9155
e-ISSN 1361-6560
Zeitschrift Physics in Medicine and Biology
Quellenangaben Band: 64, Heft: 15, Seiten: , Artikelnummer: 155016 Supplement: ,
Verlag Institute of Physics Publishing (IOP)
Verlagsort Bristol
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Radiation Medicine (IRM)