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Gonzales García, I. ; Milbank, E.* ; Diéguez, C.* ; López, M.* ; Contreras, C.*

Glucagon, GLP-1 and thermogenesis.

Int. J. Mol. Sci. 20:3445 (2019)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Brown adipose tissue (BAT) thermogenesis is a conserved mechanism to maintain body temperature in mammals. However, since BAT contribution to energy expenditure can represent a relevant modulator of metabolic homeostasis, many studies have focused on the nervous system and endocrine factors that control the activity of this tissue. There is long-established evidence that the counter-regulatory hormone glucagon negatively influences energy balance, enhances satiety, and increases energy expenditure. Despite compelling evidence showing that glucagon has direct action on BAT thermogenesis, recent findings are questioning this conventional attribute of glucagon action. Glucagon like peptide-1 (GLP-1) is an incretin secreted by the intestinal tract which strongly decreases feeding, and, furthermore, improves metabolic parameters associated with obesity and diabetes. Therefore, GLP-1 receptors (GLP-1-R) have emerged as a promising target in the treatment of metabolic disorders. In this short review, we will summarize the latest evidence in this regard, as well as the current therapeutic glucagon- and GLP-1-based approaches to treating obesity.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Glucagon ; Glp1 ; Thermogenesis ; Brown Adipose Tissue ; Browning ; Hypothalamic Control Of Energy Balance; Brown Adipose-tissue; Dependent Insulinotropic Polypeptide; Spontaneous Meal Size; Invariant Nkt Cells; Killer T-cells; Food-intake; Peptide-1 Receptor; Hypothalamic Ampk; Thyroid-hormones; Gene-expression
Sprache
Veröffentlichungsjahr 2019
HGF-Berichtsjahr 2019
ISSN (print) / ISBN 1661-6596
e-ISSN 1422-0067
Zeitschrift International Journal of Molecular Sciences
Quellenangaben Band: 20, Heft: 14, Seiten: , Artikelnummer: 3445 Supplement: ,
Verlag MDPI
Verlagsort Basel
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Obesity (IDO)
POF Topic(s) 30201 - Metabolic Health
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502200-001
DOI 10.3390/ijms20143445
WOS ID WOS:000480449300069
Scopus ID 85070463120
PubMed ID 31337027
Erfassungsdatum 2019-08-13
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