Alexander, H.* ; Paller, A.S.* ; Traidl-Hoffmann, C. ; Beck, L.A.* ; de Benedetto, A.* ; Dhar, S.* ; Girolomoni, G.* ; Irvine, A.D.* ; Spuls, P.* ; Su, J.* ; Thyssen, J.P.* ; Vestergaard, C.* ; Werfel, T.* ; Wollenberg, A.* ; Deleuran, M.* ; Flohr, C.*
The role of bacterial skin infections in atopic dermatitis: Expert statement and review from the International Eczema Council Skin Infection Group.
Br. J. Dermatol. 182, 1331-1342 (2019)
Patients with atopic dermatitis (AD) have an increased risk of bacterial skin infections, which cause significant morbidity and, if untreated, may become systemic. Staphylococcus aureus colonizes the skin of most patients with AD and is the most common organism to cause infections. Overt bacterial infection is easily recognized by the appearance of weeping lesions, honey-coloured crusts and pustules. However, the wide variability in clinical presentation of bacterial infection in AD and the inherent features of AD – cutaneous erythema and warmth, oozing associated with oedema, and regional lymphadenopathy – overlap with those of infection, making clinical diagnosis challenging. Furthermore, some features may be masked because of anatomical site- and skin-type-specific features, and the high frequency of S. aureus colonization in AD makes positive skin swab culture of suspected infection unreliable as a diagnostic tool. The host mechanisms and microbial virulence factors that underlie S. aureus colonization and infection in AD are incompletely understood. The aim of this article is to present the latest evidence from animal and human studies, including recent microbiome research, to define the clinical features of bacterial infections in AD, and to summarize our current understanding of the host and bacterial factors that influence microbial colonization and virulence.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Typ der Hochschulschrift
Herausgeber
Schlagwörter
Resistant Staphylococcus-aureus; Innate Immune-response; Methicillin-resistant; Topical Corticosteroids; Antimicrobial Peptides; Filaggrin Expression; Systemic Infections; Clinical-features; Cytokine Milieu; Increased Risk
Keywords plus
Sprache
englisch
Veröffentlichungsjahr
2019
Prepublished im Jahr
HGF-Berichtsjahr
2019
ISSN (print) / ISBN
0007-0963
e-ISSN
1365-2133
ISBN
Bandtitel
Konferenztitel
Konferzenzdatum
Konferenzort
Konferenzband
Quellenangaben
Band: 182,
Heft: 6,
Seiten: 1331-1342
Artikelnummer: ,
Supplement: ,
Reihe
Verlag
Wiley
Verlagsort
111 River St, Hoboken 07030-5774, Nj Usa
Tag d. mündl. Prüfung
0000-00-00
Betreuer
Gutachter
Prüfer
Topic
Hochschule
Hochschulort
Fakultät
Veröffentlichungsdatum
0000-00-00
Anmeldedatum
0000-00-00
Anmelder/Inhaber
weitere Inhaber
Anmeldeland
Priorität
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Environmental Medicine (IEM)
POF Topic(s)
30202 - Environmental Health
Forschungsfeld(er)
Allergy
PSP-Element(e)
G-503400-001
Förderungen
Copyright
Erfassungsdatum
2019-11-06