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Teckentrup, V.* ; Neubert, S.* ; Santiago, J.C. ; Hallschmid, M. ; Walter, M.* ; Kroemer, N.B.*

Non-invasive stimulation of vagal afferents reduces gastric frequency.

Brain Stimul. 13, 470-473 (2020)
Verlagsversion Forschungsdaten DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Metabolic feedback between the gut and the brain relayed via the vagus nerve contributes to energy homeostasis. We investigated in healthy adults whether non-invasive stimulation of vagal afferents impacts energy homeostasis via efferent effects on metabolism or digestion. In a randomized crossover design, we applied transcutaneous auricular vagus nerve stimulation (taVNS) while recording efferent metabolic effects using simultaneous electrogastrography (EGG) and indirect calorimetry. We found that taVNS reduced gastric myoelectric frequency (p = .008), but did not alter resting energy expenditure. We conclude that stimulating vagal afferents induces gastric slowing via vagal efferents without acutely affecting net energy expenditure at rest. Collectively, this highlights the potential of taVNS to modulate digestion by activating the dorsal vagal complex. Thus, taVNS-induced changes in gastric frequency are an important peripheral marker of brain stimulation effects.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Transcutaneous Auricular Vagus Nerve Stimulation ; Tavns ; Electrogastrogram ; Resting Energy Expenditure ; Energy Homeostasis; Vagus Nerve-stimulation; Brain-stem; Dopamine; Vagotomy
Sprache
Veröffentlichungsjahr 2020
Prepublished im Jahr 2019
HGF-Berichtsjahr 2019
ISSN (print) / ISBN 1935-861X
e-ISSN 1876-4754
Zeitschrift Brain stimulation
Quellenangaben Band: 13, Heft: 2, Seiten: 470-473 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort New York, NY
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)
POF Topic(s) 90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502400-001
DOI 10.1016/j.brs.2019.12.018
WOS ID WOS:000509471600037
Scopus ID 85077010051
PubMed ID 31884186
Erfassungsdatum 2020-01-14
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