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Klobeck, H.G.* ; Bornkamm, G.W.* ; Combriato, G.* ; Mocikat, R. ; Pohlenz, H.D.* ; Zachau, H.G.*

Subgroup IV of human immunoglobulin K light chains is encoded by a single germline gene.

Nucleic Acids Res. 13, 6515-6529 (1985)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
The series of studies on the human K light chain genes of the various subgroups is concluded by this report on the isolation and nucleotide sequence determination of a functional VKIV gene (abbreviations ref. 1) and its germline counterpart. The rearranged gene which stems from a lymphoid cell line and the germline gene differ in four nucleotides which can be attributed to somatic mutations; three of the mutations are clustered in CDR3. The germline gene regions of two unrelated individuals were identical over a stretch of 1267 bp. By hybridization experiments it is shown that the human K locus contains only one VKIV gene. In 16 lymphoid cell lines studied here, the VKIV gene is frequently deleted or aberrantly rearranged which may be a consequence of peculiarities of its function and/or its structural organization.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Sprache englisch
Veröffentlichungsjahr 1985
HGF-Berichtsjahr 1985
ISSN (print) / ISBN 0305-1048
e-ISSN 1362-4962
Zeitschrift Nucleic Acids Research
Quellenangaben Band: 13, Heft: 18, Seiten: 6515-6529 Artikelnummer: , Supplement: ,
Verlag Oxford University Press
Begutachtungsstatus Peer reviewed
Institut(e) AG Translationale Molekulare Immunologie (TMI)
DOI 10.1093/nar/13.18.6515
PubMed ID 2997712
Erfassungsdatum 2020-02-13
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