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Elgebaly, H.* ; Germoush, M.* ; Mosa, N.* ; Zahou, F.* ; Soffar, A.* ; Alotaibi, N.* ; Qarmush, M.* ; Hussein, O.* ; Bin-Jumah, M.* ; Hassanein, E.* ; Hernandez-Bautista, R. ; Mahmoud, A.M.*

Adenium obesum flowers extract mitigates testicular injury and oxidative stress in streptozotocin-induced diabetic rats.

Int. J. Pharm. 16, 310-318 (2020)
Verlagsversion DOI
Open Access Hybrid
Creative Commons Lizenzvertrag
Background and Objective: Diabetes Mellitus (DM) is a major healthcare problem worldwide and considerable evidence proved its negative impact on the male reproductive system. Adenium obesum is an interesting medicinal plant with a wide range of bioactivities. The current study examined the protective effects of A. obesum flower extract (AOE) on testicular injury in streptozotocin (STZ)-induced type I diabetic rats. Materials and Methods: Diabetes was induced by a single injection of 50 mg kg(-1) STZ. Diabetic rats received 250 and 500 mg kg(-1) AOE for 21 days and samples were collected for analysis. Results: As compared to the diabetic control rats, treatment with AOE increased serum testosterone, Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH) levels, decreased testicular thiobarbituric acid reactive substances (TBARS) content, effectively enhanced reduced glutathione (GSH) content and superoxide dismutase (SOD) activity. Additionally, AGE effectively inhibited diabetes-induced testicular tissue injuryand prevented inflammatoryand apoptotic responses manifested by decreased TNF-alpha, IL-6 and Bax and increased Bcl-2. Conclusion: These results demonstrated that AGE mitigates testicular injury, oxidative stress, inflammatory response and apoptotic cell death in STZ-induced diabetic rats.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Desert Rose ; Oxidative Injury ; Inflammation ; Antioxidants ; Phenolics ; Diabetes ; Testosterone ; Apoptosis; Germ-cell Death; Mellitus; Inflammation; Damage; Apoptosis; Activation; Protects; Taurine; Roem.
Sprache englisch
Veröffentlichungsjahr 2020
HGF-Berichtsjahr 2020
ISSN (print) / ISBN 0378-5173
e-ISSN 1873-3476
Zeitschrift International Journal of Pharmaceutics
Quellenangaben Band: 16, Heft: 4, Seiten: 310-318 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Obesity (IDO)
POF Topic(s) 30502 - Diabetes: Pathophysiology, Prevention and Therapy
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-508600-014
DOI 10.3923/ijp.2020.310.318
WOS ID WOS:000534611100004
Erfassungsdatum 2020-06-08
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