PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Ovsepian, S.V. ; O´Leary, V.B.* ; Vesselkin, N.P.*

Evolutionary origins of chemical synapses.

In:. Amsterdam [u.a.]: Elsevier, 2020. 1-21 (Vitam. Horm. ; 114)
DOI
Synaptic transmission is a fundamental neurobiological process by which neurons interact with each other and non-neuronal cells. It involves release of active substances from the presynaptic neuron onto receptive elements of postsynaptic cells, inducing waves of spreading electrochemical response. While much has been learned about the cellular and molecular mechanisms driving and governing transmitter release and sensing, the evolutionary origin of synaptic connections remains obscure. Herein, we review emerging evidence and concepts suggesting that key components of chemical synapse arose independently from neurons, in different functional and biological contexts, before the rise of multicellular living forms. We argue that throughout evolution, distinct synaptic constituents have been co-opted from ancestral forms for a new role in early metazoan, leading to the rise of chemical synapses and neurotransmission. Such a mosaic model of the origin of chemical synapses agrees with and supports the pluralistic hypothesis of evolutionary change.
Altmetric
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Sammelbandbeitrag/Buchkapitel
Schlagwörter Chemical Synapse ; Exaptation ; Functional Integration ; Gap Junctions ; Paracrine Signaling ; Snare Proteins ; Synaptic Evolution; Electrical Synapses; Gap-junctions; Postnatal-development; Neuronal Domains; Rat; Communication; Transmission; Release; Protein; Nerve
Sprache englisch
Veröffentlichungsjahr 2020
HGF-Berichtsjahr 2020
ISSN (print) / ISBN 0083-6729
e-ISSN 2162-2620
Zeitschrift Vitamins and Hormones
Quellenangaben Band: 114, Heft: , Seiten: 1-21 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam [u.a.]
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biological and Medical Imaging (IBMI)
POF Topic(s) 30205 - Bioengineering and Digital Health
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-505500-001
Förderungen Charles University
MEYS under the NPU I program
DOI 10.1016/bs.vh.2020.04.009
WOS ID WOS:000612641100002
Scopus ID 85087395425
Erfassungsdatum 2020-07-21
[➜Korrektur melden]