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Stefan, N.

Metabolically healthy and unhealthy normal weight and obesity.

Endocrinol. Metab. 35, 487–493 (2020)
Verlagsversion DOI PMC
Free journal
Creative Commons Lizenzvertrag
Increased fat mass is an established risk factor for the cardiometabolic diseases type 2 diabetes and cardiovascular disease (CVD) and is associated with increased risk of all-cause and CVD mortality. However, also very low fat mass associates with such an increased risk. Whether impaired metabolic health, characterized by hypertension, dyslipidemia, hyperglycemia, insulin resistance, and subclinical inflammation, may explain part of the elevated risk of cardiometabolic diseases that is found in many subjects with very low fat mass, as it does in many obese subjects, is unknown. An important pathomechanism of impaired metabolic health is disproportionate fat distribution. In this article the risk of cardiometabolic diseases and mortality in subjects with metabolically healthy and unhealthy normal weight and obesity is summarized. Furthermore, the change of metabolic health during a longer period of follow-up and its impact on cardiometabolic diseases is being discussed. Finally, the implementation of the concept of metabolic health in daily clinical practice is being highlighted.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Fatty Liver ; Insulin Resistance ; Metabolic Health ; Normal Weight ; Obesity ; Obesity, Abdominal ; Subclinical Inflammation; All-cause; Fetuin-a; Disease; Risk; Overweight; Consequences; Association; Phenotypes; Mortality; Genetics
Sprache englisch
Veröffentlichungsjahr 2020
HGF-Berichtsjahr 2020
ISSN (print) / ISBN 2093-596X
e-ISSN 2093-5978
Zeitschrift Endocrinology and Metabolism
Quellenangaben Band: 35, Heft: 3, Seiten: 487–493 Artikelnummer: , Supplement: ,
Verlag Korean Endocrine Society
Verlagsort Seoul
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)
POF Topic(s) 90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502400-001
Förderungen German Federal Ministry of Education and Research to the German Centre of Diabetes Researc
DOI 10.3803/EnM.2020.301
WOS ID WOS:000596724400001
PubMed ID 32814419
Erfassungsdatum 2020-10-20
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