PuSH - Publikationsserver des Helmholtz Zentrums München

Stefan, N.

Metabolically healthy and unhealthy normal weight and obesity.

Endocrinol. Metab. 35, 487–493 (2020)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Increased fat mass is an established risk factor for the cardiometabolic diseases type 2 diabetes and cardiovascular disease (CVD) and is associated with increased risk of all-cause and CVD mortality. However, also very low fat mass associates with such an increased risk. Whether impaired metabolic health, characterized by hypertension, dyslipidemia, hyperglycemia, insulin resistance, and subclinical inflammation, may explain part of the elevated risk of cardiometabolic diseases that is found in many subjects with very low fat mass, as it does in many obese subjects, is unknown. An important pathomechanism of impaired metabolic health is disproportionate fat distribution. In this article the risk of cardiometabolic diseases and mortality in subjects with metabolically healthy and unhealthy normal weight and obesity is summarized. Furthermore, the change of metabolic health during a longer period of follow-up and its impact on cardiometabolic diseases is being discussed. Finally, the implementation of the concept of metabolic health in daily clinical practice is being highlighted.
Altmetric
Weitere Metriken?
[➜Einloggen]
Zusatzinfos bearbeiten [➜Einloggen]
Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Fatty Liver ; Insulin Resistance ; Metabolic Health ; Normal Weight ; Obesity ; Obesity, Abdominal ; Subclinical Inflammation; All-cause; Fetuin-a; Disease; Risk; Overweight; Consequences; Association; Phenotypes; Mortality; Genetics
ISSN (print) / ISBN 2093-596X
e-ISSN 2093-5978
Zeitschrift Endocrinology and Metabolism
Quellenangaben Band: 35, Heft: 3, Seiten: 487–493 Artikelnummer: , Supplement: ,
Verlag Korean Endocrine Society
Verlagsort Seoul
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)
Förderungen German Federal Ministry of Education and Research to the German Centre of Diabetes Researc