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Metwaly, A.* ; Dunkel, A.* ; Waldschmitt, N.* ; Durai Raj, A.C. ; Lagkouvardos, I.* ; Corraliza, A.M.* ; Mayorgas, A.* ; Martinez-Medina, M.* ; Reiter, S.* ; Schloter, M. ; Hofmann, T.* ; Allez, M.* ; Panes, J.* ; Salas, A.* ; Haller, D.*

Integrated microbiota and metabolite profiles link Crohn’s disease to sulfur metabolism.

Nat. Commun. 11:4322 (2020)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Gut microbial and metabolite alterations have been linked to the pathogenesis of inflammatory bowel diseases. Here we perform a multi-omics microbiome and metabolite analysis of a longitudinal cohort of Crohn’s disease patients undergoing autologous hematopoietic stem cell transplantation, and investigational therapy that induces drug free remission in a subset of patients. Via comparison of patients who responded and maintained remission, responded but experienced disease relapse and patients who did not respond to therapy, we identify shared functional signatures that correlate with disease activity despite the variability of gut microbiota profiles at taxonomic level. These signatures reflect the disease state when transferred to gnotobiotic mice. Taken together, the integration of microbiome and metabolite profiles from human cohort and mice improves the predictive modelling of disease outcome, and allows the identification of a network of bacteria-metabolite interactions involving sulfur metabolism as a key mechanism linked to disease activity in Crohn’s disease.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Stem-cell Transplantation; Gut Microbiome; Functional-characterization; Bacteria; Inflammation; Dysbiosis; Sequences; Therapy; Toxin
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Zeitschrift Nature Communications
Quellenangaben Band: 11, Heft: 1, Seiten: , Artikelnummer: 4322 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Comparative Microbiome Analysis (COMI)
Förderungen Projekt DEAL
Helmsley Charitable Trust (IBDOT)
Deutsche Forschungsgemeinschaft (DFG, German Research foundation)
Leona and Harry Helmsley Charitable Trust (IBDOT Consortium)