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The aging mouse microbiome has obesogenic characteristics.
Genome Med. 12:87 (2020)
Background During aging, there is a physiological decline, an increase of morbidity and mortality, and a natural change in the gut microbiome. In this study, we investigated the influence of the gut microbiome on different metabolic parameters in adult and aged mice. Methods Fecal and blood samples from adult (n = 42, 100-300 days) and aging (n = 32, 550-750 days) mice were collected. Microbiome analysis was done using QIIME2. Mouse weight and body composition were measured using NMR, and insulin and leptin levels in the blood were measured with Mouse Adipokine Magnetic Bead Panel kit. Fecal microbiota transplantation experiments from adult and aged mice into young germ-free mice were carried out in order to examine the effect of the gut microbiome of adult and aging mice on weight, body composition, insulin, and leptin. Results We demonstrate that the microbiomes from adult and aged mice are distinguishable. We also report changes in metabolic parameters as we observed significantly higher weight and fat mass and low lean mass in aged compared to adult mice along with high insulin and leptin levels in the blood. The transplanted gut microbiome from aged mice transferred part of the phenotypes seen in aged mice. Fat body mass and insulin levels were higher in the mice who received feces from aged mice than mice receiving feces from adult mice. In addition, they consumed more food and had a higher respiratory quotient compared to mice receiving adult feces. Conclusions We conclude that aged mice have a gut microbiota with obesogenic characteristics. In addition, the gut bacterial population itself is sufficient to induce some of the manifestations of obesity.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
10.675
2.348
4
9
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Aging ; Microbiome ; Metabolism ; Fecal Microbiota Transplantation; Gut Microbiome; Obesity; Susceptibility; Insulin; Weight; Health; Diet
Sprache
englisch
Veröffentlichungsjahr
2020
HGF-Berichtsjahr
2020
ISSN (print) / ISBN
1756-994X
e-ISSN
1756-994X
Zeitschrift
Genome Medicine
Quellenangaben
Band: 12,
Heft: 1,
Artikelnummer: 87
Verlag
BioMed Central
Verlagsort
Campus, 4 Crinan St, London N1 9xw, England
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Experimental Genetics (IEG)
POF Topic(s)
90000 - German Center for Diabetes Research
Forschungsfeld(er)
Genetics and Epidemiology
PSP-Element(e)
G-501900-069
WOS ID
WOS:000579379600001
Scopus ID
85092469242
PubMed ID
33046129
Erfassungsdatum
2020-10-14