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Blank, S. ; Grosch, J. ; Ollert, M.* ; Bilò, M.B.*

Precision medicine in hymenoptera venom allergy: Diagnostics, biomarkers, and therapy of different endotypes and phenotypes.

Front. Immunol. 11:579409 (2020)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Allergic reactions to stings of Hymenoptera species may be severe and are potentially fatal deviations of the immunological response observed in healthy individuals. However, venom-specific immunotherapy (VIT) is an immunomodulatory approach able to cure venom allergy in the majority of affected patients. An appropriate therapeutic intervention and the efficacy of VIT not only depend on a conclusive diagnosis, but might also be influenced by the patient-specific manifestation of the disease. As with other diseases, it should be borne in mind that there are different endotypes and phenotypes of venom allergy, each of which require a patient-tailored disease management and treatment scheme. Reviewed here are different endotypes of sting reactions such as IgE-mediated allergy, asymptomatic sensitization or a simultaneous presence of venom allergy and mast cell disorders including particular considerations for diagnosis and therapy. Additionally, phenotypical manifestations of venom allergy, as e.g. differences in age of onset and disease severity, multiple sensitization or patients unsusceptible to therapy, are described. Moreover, biomarkers and diagnostic strategies that might reflect the immunological status of the patient and their value for therapeutic guidance are discussed. Taken together, the increasing knowledge of different disease manifestations in venom hypersensitivity and the growing availability of diagnostic tools open new options for the classification of venom allergy and, hence, for personalized medical approaches and precision medicine in Hymenoptera venom allergy.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Allergy Diagnosis ; Biomarkers ; Immune Tolerance ; Molecular Allergology ; Precision Medicine ; Venom Allergen ; Venom-specific Immunotherapy ; Hymenoptera Venom Allergy; Api M 1; Stinging Insect Hypersensitivity; Rves V 5; Component-resolved Diagnosis; Yellow Jacket Venom; Regulatory B-cells; Cd4(+) T-cells; Hla Class-i; Honeybee Venom; Anaphylactic Reactions
ISSN (print) / ISBN 1664-3224
e-ISSN 1664-3224
Zeitschrift Frontiers in Immunology
Quellenangaben Band: 11, Heft: , Seiten: , Artikelnummer: 579409 Supplement: ,
Verlag Frontiers
Verlagsort Avenue Du Tribunal Federal 34, Lausanne, Ch-1015, Switzerland
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Allergy Research (IAF)
Förderungen Bencard Allergy GmbH, Munich, Germany
FNR PRIDE Doctoral Training Unit program
Personalized Medicine Consortium (PMC) of Luxembourg (SYS-T-ACT)
Helmholtz Association, Future Topic "Immunology and Inflammation"