PuSH - Publikationsserver des Helmholtz Zentrums München

Papaioannou, N.E.* ; Salei, N.* ; Rambichler, S.* ; Ravi, K.* ; Popovic, J.* ; Küntzel, V.* ; Lehmann, C.H.K.* ; Fiancette, R.* ; Salvermoser, J.* ; Gajdasik, D.W.* ; Mettler, R.* ; Messerer, D.* ; Carrelha, J.* ; Ohnmacht, C. ; Haller, D.* ; Stumm, R.* ; Straub, T.* ; Jacobsen, S.E.W.* ; Schulz, C.* ; Withers, D.R.* ; Schotta, G.* ; Dudziak, D.* ; Schraml, B.U.*

Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice.

Nat. Commun. 12:464 (2021)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Conventional dendritic cells (cDC) are key activators of naive T cells, and can be targeted in adults to induce adaptive immunity, but in early life are considered under-developed or functionally immature. Here we show that, in early life, when the immune system develops, cDC2 exhibit a dual hematopoietic origin and, like other myeloid and lymphoid cells, develop in waves. Developmentally distinct cDC2 in early life, despite being distinguishable by fate mapping, are transcriptionally and functionally similar. cDC2 in early and adult life, however, are exposed to distinct cytokine environments that shape their transcriptional profile and alter their ability to sense pathogens, secrete cytokines and polarize T cells. We further show that cDC2 in early life, despite being distinct from cDC2 in adult life, are functionally competent and can induce T cell responses. Our results thus highlight the potential of harnessing cDC2 for boosting immunity in early life.
Altmetric
Weitere Metriken?
[➜Einloggen]
Zusatzinfos bearbeiten [➜Einloggen]
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Zeitschrift Nature Communications
Quellenangaben Band: 12, Heft: 1, Seiten: , Artikelnummer: 464 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Allergy Research (IAF)
Förderungen SFB914
Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) Emmy Noether Grant
DFG
DZHK (German Centre for Cardiovascular Research)
BMBF (German Ministry of Education and Research)
Agency national research (ANR)/German Research Foundation program
ERC Starting Grant